Fever of unknown origin other diagnostic studies: Difference between revisions
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| style="vertical-align: middle; padding: 5px;" align=center | [[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | | style="vertical-align: middle; padding: 5px;" align="center" |[[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | ||
| style="vertical-align: middle; padding: 5px;" align=center | [[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | | style="vertical-align: middle; padding: 5px;" align="center" |[[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | ||
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{{Fever of unknown origin}} | {{Fever of unknown origin}} | ||
{{CMG}} | {{CMG}} | ||
{{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; | {{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO | ||
==Overview== | |||
Other than laboratory work up some other investigation listed below may be helpful in finding cause of FUO.<ref name="pmid26031980">{{cite journal| author=Mulders-Manders C, Simon A, Bleeker-Rovers C| title=Fever of unknown origin. | journal=Clin Med (Lond) | year= 2015 | volume= 15 | issue= 3 | pages= 280-4 | pmid=26031980 | doi=10.7861/clinmedicine.15-3-280 | pmc=4953114 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26031980 }}</ref><ref name="pmid23977936">{{cite journal| author=Kaya A, Ergul N, Kaya SY, Kilic F, Yilmaz MH, Besirli K | display-authors=etal| title=The management and the diagnosis of fever of unknown origin. | journal=Expert Rev Anti Infect Ther | year= 2013 | volume= 11 | issue= 8 | pages= 805-15 | pmid=23977936 | doi=10.1586/14787210.2013.814436 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23977936 }}</ref> | |||
==Other Diagnostic Studies== | |||
===Lymph Node Biopsy=== | |||
Lymph node biopsy may be useful when suspecting [[lymphoma]], [[lymphogranuloma venereum]], [[toxoplasmosis]], and [[Kikuchi disease]]. Granulomas in lymph node biopsies may indicate a disorder associated with granulomatous [[inflammation]] (eg, [[tuberculosis]], [[sarcoidosis]]) or [[lymphoma]]. The preferred lymph nodes to biopsy are the posterior cervical, epitrochlear, or supraclavicular nodes. | |||
===Bone Marrow Biopsy=== | |||
Bone marrow biopsy may be considered when there are clues for hematologic malignancies. | |||
===Naproxen Test=== | |||
[[Naproxen]] test can be used to distinguish neoplastic fever from other etiologies of FUO. | |||
At a dosage of 375 mg twice daily, [[naproxen]] demonstrated no antipyretic activity against fever in patients with occult infection. Defervescence within 12 hours occurs in almost all patients with neoplastic fever. The [[naproxen]] test is considered positive when there is a rapid or sustained abatement of fever during the 3 days of the trial period. Fever recurs after discontinuation of [[naproxen]] in patients with neoplasms.<ref>{{Cite journal| issn = 0147-9563| volume = 16| issue = 2| pages = 122–127| last = Chang| first = J. C.| title = How to differentiate neoplastic fever from infectious fever in patients with cancer: usefulness of the naproxen test| journal = Heart & Lung: The Journal of Critical Care| date = 1987-03| pmid = 3028981}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
[[Category:Ailments of unknown etiology]] | |||
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Latest revision as of 23:41, 27 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Overview
Other than laboratory work up some other investigation listed below may be helpful in finding cause of FUO.[1][2]
Other Diagnostic Studies
Lymph Node Biopsy
Lymph node biopsy may be useful when suspecting lymphoma, lymphogranuloma venereum, toxoplasmosis, and Kikuchi disease. Granulomas in lymph node biopsies may indicate a disorder associated with granulomatous inflammation (eg, tuberculosis, sarcoidosis) or lymphoma. The preferred lymph nodes to biopsy are the posterior cervical, epitrochlear, or supraclavicular nodes.
Bone Marrow Biopsy
Bone marrow biopsy may be considered when there are clues for hematologic malignancies.
Naproxen Test
Naproxen test can be used to distinguish neoplastic fever from other etiologies of FUO.
At a dosage of 375 mg twice daily, naproxen demonstrated no antipyretic activity against fever in patients with occult infection. Defervescence within 12 hours occurs in almost all patients with neoplastic fever. The naproxen test is considered positive when there is a rapid or sustained abatement of fever during the 3 days of the trial period. Fever recurs after discontinuation of naproxen in patients with neoplasms.[3]
References
- ↑ Mulders-Manders C, Simon A, Bleeker-Rovers C (2015). "Fever of unknown origin". Clin Med (Lond). 15 (3): 280–4. doi:10.7861/clinmedicine.15-3-280. PMC 4953114. PMID 26031980.
- ↑ Kaya A, Ergul N, Kaya SY, Kilic F, Yilmaz MH, Besirli K; et al. (2013). "The management and the diagnosis of fever of unknown origin". Expert Rev Anti Infect Ther. 11 (8): 805–15. doi:10.1586/14787210.2013.814436. PMID 23977936.
- ↑ Chang, J. C. (1987-03). "How to differentiate neoplastic fever from infectious fever in patients with cancer: usefulness of the naproxen test". Heart & Lung: The Journal of Critical Care. 16 (2): 122–127. ISSN 0147-9563. PMID 3028981. Check date values in:
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