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==Overview==
==Overview==
'''Psittacosis''' [[zoonosis|zoonotic]] [[infectious diseases|infectious disease]] caused by a [[bacterium]] called ''[[Chlamydophila psittaci]]'' (formerly ''[[Chlamydia psittaci]]'') and contracted not only from parrots, such as macaws, cockatiels and budgerigars, but also from pigeons, sparrows, ducks, hens, sea gulls and many other species of bird. The incidence of infection in canaries and finches is believed to be lower than in psittacine birds.
Psittacosis is a [[zoonosis|zoonotic]] [[infectious diseases|infectious disease]] caused by a [[bacterium]] called ''[[Chlamydophila psittaci]]'' (formerly ''[[Chlamydia psittaci]]''). The disease is contracted not only from parrots, such as macaws, cockatiels, and budgerigars, but also from pigeons, sparrows, ducks, hens, seagulls, and many other [[species]] of birds. The [[incidence]] of [[infection]] in canaries and finches is believed to be lower than in psittacine birds. As a systemic [[zoonotic]] [[infection]] with protean clinical features, the major [[risk factor]] is exposure to birds. Hence, bird owners, [[Veterinarian|veterinarians]], those involved with breeding and selling birds, and commercial [[poultry]] processors are most at risk. Patients typically present with 1 week of [[fevers]], [[headache]], [[myalgias]], and a nonproductive [[cough]]. Although [[pneumonia]] is the most common manifestation, all [[organ systems]] can be involved. [[Serology]] remains the mainstay of diagnosis; however, [[polymerase chain reaction]] techniques offer a rapid and specific alternative. [[Doxycycline]] is the treatment of choice.
As a systemic zoonotic infection with protean clinical features, the major risk factor is exposure to birds. Hence, bird owners, veterinarians, those involved with breeding and selling birds, and commercial poultry processors are most at risk. Patients typically present with 1 week of fevers, headache, myalgias, and a nonproductive cough. Although pneumonia is the most common manifestation, all organ systems can be involved. Serology remains the mainstay of diagnosis; however, polymerase chain reaction techniques offer a rapid and specific alternative. Doxycycline is the treatment of choice.


==Historical perspective==
==Historical perspective==
The word psittacosis is derived from the Greek work 'Psittakos', which means parrot. Psittacosis infects psittacines (parrots, parakeets, cockatoos).
The word [[psittacosis]] is derived from the Greek work "psittakos," which means parrot. [[Psittacosis]] [[Infect|infects]] psittacines (parrots, parakeets, cockatoos). "[[Ornithosis]]" is the term used if it infects other types of [[birds]]. It is assumed that the origin of psittacosis is in South America, where the rain forests are populated with many [[species]] of psittacine birds. Aboriginal tribes were fond of these birds and used their feathers as parts of their ceremonial clothing. Other psittacine birds were kept as pets in aboriginal villages.
'Ornithosis' is a term used if it infects other types of birds. It is assumed that the origin of psittacosis is in South America, where the rain forests are populated with many species of psittacine birds. Aboriginal tribes were fond of these birds and used their feathers as parts of their ceremonial clothing. Other psittacine birds were kept as pets in aboriginal villages. <ref name="pmid1723942">{{cite journal| author=Wehrle B, Chiquet M| title=Tenascin is accumulated along developing peripheral nerves and allows neurite outgrowth in vitro.| journal=Development | year= 1990 | volume= 110 | issue= 2 | pages= 401-15 | pmid=1723942 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1723942  }} </ref>


==Classification==
==Classification==
C psittaci may be classified into eight serovars according to variation in the major outer membrane protein (MOMP): serovar A to F, WC and M56.<ref name="pmid9765811">{{cite journal| author=Vanrompay D, Butaye P, Sayada C, Ducatelle R, Haesebrouck F| title=Characterization of avian Chlamydia psittaci strains using omp1 restriction mapping and serovar-specific monoclonal antibodies. | journal=Res Microbiol | year= 1997 | volume= 148 | issue= 4 | pages= 327-33 | pmid=9765811 | doi=10.1016/S0923-2508(97)81588-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9765811  }} </ref>
There is no established classification system for [[psittacosis]].


==Pathophysiology==
==Pathophysiology==
The major risk factor for acquiring psittacosis is exposure to birds. Transmission can occur either by inhalation of aerosolized organisms in form of dried feces or respiratory secretions or by direct contact with birds.
The major [[risk factor]] for acquiring [[psittacosis]] is exposure to [[birds]]. [[Transmission (medicine)|Transmission]] can occur either by inhalation of aerosolized organisms in form of dried [[feces]] or [[Respiratory system|respiratory]] secretions or by direct contact with [[birds]]. The exact [[molecular]] details of [[bacterial]] uptake are not well understood. It is speculated that [[chlamydial]] cell contact is a two-step process: reversible binding followed by irreversible attachment. The key to understanding the [[pathogenesis]] of [[C. psittaci|''C. psittaci'']] is that frequent and repeated episodes of reinfection are needed for the development of severe [[disease]]. Several studies also highlighted the critical importance of host [[microfilaments]], [[microtubules]], and [[Microtubule-associated protein|microtubule motor protein]]<nowiki/>s ([[kinesin]] and [[dynein]]) for uptake and [[intracellular]] development of [[C. psittaci|''C. psittaci'']] and other [[Chlamydia infection|''Chlamydia'' spp]]. As with other [[intracellular]] [[zoonoses]] such as [[Q fever]] and [[brucellosis]], the clinical conditions associated with [[psittacosis]] have been seen in many [[organ systems]] such as the [[pulmonary]], [[hepatic]], and [[CNS|central nervous systems]].


==Causes==
==Causes==
Psittacosis is caused by the organism Chlamydia psittaci. Chlamydia is understood to be a Gram-negative bacterium belonging to the genus Chlamydia or Chlamydophila in the family of Chlamydiaceae together with  Parachlamydiaceae, Waddliaceae and Simkaniaceae in the order Chlamydiales, class and phylum Chlamydiae. Chlamydiales are obligate intracellular infectious agents in eukaryotic cells characterized by a unique developmental replication cycle.<ref name="pmid229510">{{cite journal| author=de Rossi G, Focacci C| title=Early detection of craniosynostosis by 99mTc-pyrophosphate bone scanning. | journal=Radiol Diagn (Berl) | year= 1979 | volume= 20 | issue= 3 | pages= 405-9 | pmid=229510 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=229510  }} </ref>
[[Psittacosis]] is caused by the [[organism]] [[Chlamydia psittaci|''Chlamydia psittaci'']]. [[Chlamydia]] is understood to be a [[Gram-negative bacteria|Gram-negative]] [[bacterium]] belonging to the [[genus]] ''[[Chlamydia]]'' or ''[[Chlamydophila]]'' in the [[family]] ''[[Chlamydiaceae]].'' [[Parachlamydiaceae|''Parachlamydiaceae'']], [[Waddliaceae|''Waddliaceae'']], and [[Simkaniaceae|''Simkaniaceae'']]  also belong to the order [[Chlamydiales|''Chlamydiales'']], [[Class (biology)|class]] and [[Phylum (biology)|phylum]] ''[[Chlamydiae]].'' [[Chlamydiales]] are [[Obligate intracellular parasite|obligate intracellular]] infectious agents in [[eukaryotic]] cells characterized by a unique developmental replication cycle.


==Differential diagnosis==
==Differential diagnosis==
Psittacosis must be differentiated from other diseases that cause atypical pneumonia, febrile illness without localizing signs and extrapulmonary manifestations such as gastroenteritis, hepatitis, meningitis, or encephalitis. The three main diseases to differentiate psittacosis from are Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella infection as they tend to have similar clinical manifestations which can only be differentiated by taking appropriate histories and laboratpory investigations. There are other conditions to watch out for which may also present similar to psittacosis.
[[Psittacosis]] must be differentiated from other [[diseases]] that cause [[atypical pneumonia]] and [[febrile]] [[illness]] without localizing signs and extrapulmonary manifestations such as [[gastroenteritis]], [[hepatitis]], [[meningitis]], or [[encephalitis]]. The three main [[diseases]] to differentiate psittacosis from are ''[[Chlamydia pneumoniae]]'' pneumonia, ''[[Mycoplasma pneumoniae]]'' pneumonia, and [[Legionella infection|''Legionella'' infection]], as they tend to have similar clinical manifestations that can only be differentiated by taking appropriate histories and [[Laboratory information system|laboratory investigations]]. There are other conditions to watch out for which may also present similarly to psittacosis.


==Epidemiology and demographics==
==Epidemiology and demographics==
Since 1996, fewer than 50 confirmed cases were reported in the United States each year. Many more cases may occur that are not correctly diagnosed or reported.<ref name="urlDisease Listing, Psittacosis, Technical Information | CDC Bacterial, Mycotic Diseases">{{cite web |url=http://www.cdc.gov/ncidod/dbmd/diseaseinfo/psittacosis_t.htm |title=Disease Listing, Psittacosis, Technical Information &#124; CDC Bacterial, Mycotic Diseases |format= |work= |accessdate=}}</ref>. In the united states, the incidence of psittacosis is 0.01 per 100,000 persons. The prevalence and incidence of psittacosis does not vary by gender neither is there a racial predilection for psittacosis has it has been identified in all parts of the world including, Africa, china, Europe and the United states.
Since 1996, fewer than 50 confirmed cases of psittacosis have been reported in the United States each year. Many more cases may occur that are not correctly diagnosed or reported. In the United States, the [[incidence]] of [[psittacosis]] is 0.01 per 100,000 persons. The [[prevalence]] and [[incidence]] of [[psittacosis]] does not vary by gender. There is no racial predilection for [[psittacosis]], as it has been identified in all parts of the world including Africa, China, Europe, and the United States.


==Risk factors==
==Risk factors==
Bird owners, pet shop employees, persons who work in poultry processing plants, and veterinarians are at increased risk for this infection. Typical birds involved are parrots, parakeets, and budgerigars, although other animals documented with C psittaci infection include horses,<ref name="pmid4913592">{{cite journal| author=Milton SH, Craddock GN| title=Failure of capsulotomy to reduce deaths from renal ischaemia. | journal=Br J Surg | year= 1970 | volume= 57 | issue= 5 | pages= 392 | pmid=4913592 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4913592  }} </ref> cattle,<ref name="Silva-ZacariasAlfieri2009">{{cite journal|last1=Silva-Zacarias|first1=Francielle Gibson da|last2=Alfieri|first2=Amauri Alcindo|last3=Spohr|first3=Kledir Anderson Hofstaetter|last4=Lima|first4=Bruna Azevedo de Carvalho|last5=Negrão|first5=Fábio Juliano|last6=Lunardi|first6=Michele|last7=Freitas|first7=Julio Cesar de|title=Validation of a PCR Assay for Chlamydophila abortus rRNA gene detection in a murine model|journal=Brazilian Archives of Biology and Technology|volume=52|issue=spe|year=2009|pages=99–106|issn=1516-8913|doi=10.1590/S1516-89132009000700014}}</ref> and koalas,<ref name="pmid3373633">{{cite journal| author=Weigler BJ, Girjes AA, White NA, Kunst ND, Carrick FN, Lavin MF| title=Aspects of the epidemiology of Chlamydia psittaci infection in a population of koalas (Phascolarctos cinereus) in southeastern Queensland, Australia. | journal=J Wildl Dis | year= 1988 | volume= 24 | issue= 2 | pages= 282-91 | pmid=3373633 | doi=10.7589/0090-3558-24.2.282 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3373633  }} </ref>
Bird owners, pet shop employees, persons who work in poultry processing plants, and [[Veterinarian|veterinarians]] are at increased risk for contracting psittacosis. Typical birds involved are parrots, parakeets, and budgerigars. Other animals documented with ''[[C. psittaci]]'' [[infection]] include horses, cattle, and koalas, but they have not been documented to transmit the [[infection]] to [[humans]].
 
==Screening==
According to the USPSTF, there is insufficient evidence to recommend routine screening for [[psittacosis]].


==Natural history, complications and prognosis==
==Natural history, complications and prognosis==
Psittacosis, if left untreated presents as a flu like symptom or an atypical pneumonia in most cases. In the first week of psittacosis the symtoms mimic [[typhoid fever]]; prostrating high [[fever]]s, [[arthralgia]]s, [[diarrhea]], [[conjunctivitis]], [[epistaxis]] and [[leukopenia]].   [[Headache]] can be so severe that suggests [[meningitis]] and some nuchal rigidity is not unusual. Towards the end of first week stupor or even [[coma]]can result in severe cases. The second week is more akin of acute bacteraemic [[pneumococcal pneumonia]] with continuous high [[fever]]s, [[cough]] and [[dyspnea]]. Some complications include respiratory failure, acute tubular necrosis, hemolytic anemia, endocarditis, hepatitis, encephalitis and in some fatal cases death.
If left untreated, psittacosis usually presents as [[Flu|flu-like symptoms]] or an [[atypical pneumonia]]. In the first week of [[psittacosis]], the symptoms mimic [[typhoid fever|typhoid fever,]] including prostrating high [[fever]]s, [[arthralgia]]s, [[diarrhea]], [[conjunctivitis]], [[epistaxis]], and [[leukopenia]]. [[Headache]] can be so severe that it suggests [[meningitis]] and some [[nuchal rigidity]]. Towards the end of the first week, [[stupor]] or even [[Coma (patient information)|coma]] can result in severe cases. The second week is more akin to [[acute]] [[Bacteremia|bacteremic]] [[pneumococcal pneumonia]] with continuous high [[fever]]s, [[cough]], and [[dyspnea]]. Some complications include [[respiratory failure]], [[acute tubular necrosis]], [[hemolytic anemia]], [[endocarditis]], [[hepatitis]], [[encephalitis]] and, in some cases, death.


==Diagnosis==
==Diagnosis==


===History and Symptoms===
===History and Symptoms===
The hallmark of psittacosis is a flu-like reaction with a history of exposure to birds. However, history of exposure to birds may not always be present. Psittacosis is characterized by a wide range in both disease severity and in spectrum of clinical features, but it typically presents with fever, prominent headache, myalgia, and a nonproductive cough. The mainstay of diagnostic testing is serologic, although molecular techniques increasingly are utilized.
The hallmark of [[psittacosis]] is a [[Flu|flu-like]] reaction with a history of exposure to [[birds]]. However, a history of exposure to birds may not always be present. [[Psittacosis]] is characterized by a wide range in both [[disease]] severity and spectrum of clinical features, but it typically presents with [[fever]], prominent [[headache]], [[myalgia]], and a [[Cough|nonproductive cough]]. The mainstay of diagnostic testing is [[serology]], although [[molecular]] techniques are being increasingly utilized.


===Physical Examination===
===Physical Examination===
Physical examination in a patient with psittacosis includes rose spots which are called Horder's spots. Splenomegaly is frequent toward the end of first week. Diagnosis can be suspected in case of respiratory infection associated with splenomegaly and/or epistaxis.
[[Physical examination]] findings in a patient with psittacosis include [[rose spot]] rashes on the skin called Horder's spots and [[splenomegaly]], which is frequent toward the end of first week. [[Diagnosis]] can be suspected in the case of [[respiratory infection]] associated with [[splenomegaly]] and/or [[epistaxis]].


===Laboratory Findings===
===Laboratory Findings===
Exposure history is paramout to diagnosis. Bloodwork shows [[leukopenia]], [[thrombocytopenia]] and moderately elevated [[liver]] enzymes. Culture of C psittaci is demanding, requires a level 3 laboratory isolation facility because of the risk of laboratory transmission and is rarely performed.
Exposure history is critical to [[diagnosis]]. [[Complete blood count]] shows [[leukopenia]], [[thrombocytopenia]], and moderately elevated [[liver]] [[enzymes]]. Culture of ''[[C. psittaci]]'' is demanding and requires a level 3 laboratory isolation facility because of the risk of laboratory transmission, so it is rarely performed. [[Serology]] is the most widely available method for laboratory diagnosis of ''[[C. psittaci]]'' [[infection]]. [[Complement fixation]], [[Immunofluorescence|microimmunofluorescence]], and [[EIA]] are the most commonly used techniques.


===Electrocardiogram===
===Electrocardiogram===
There are no [[electrocardiogram]] findings associated with [[psittacosis]]. However, [[bradycardia]] may be noticed on [[electrocardiogram]].


===Chest X Ray===
===Chest X-Ray===
[[Chest X ray|Chest X-rays]] show [[Consolidation (medicine)|lobar consolidation]], patchy infiltrates, a diffuse whiteout of the lung field, or [[Pleural effusion|pleural effusions]].
 
===CT scan===
On high resolution [[Computed tomography|CT]], infiltrates may be nodular and surrounded by [[Ground glass opacification on CT|ground glass opacity]].


===MRI===
===MRI===
There are no [[MRI]] findings associated with [[psittacosis]].


===Echocardiography or ultrasound===
===Echocardiography or ultrasound===
There are no [[echocardiography]] or [[ultrasound]] findings associated with [[psittacosis]].


===Other imaging findings===
===Other imaging findings===
There are no other imaging findings associated with [[psittacosis]].


===Other diagnostic studies===
===Other diagnostic studies===
[[Biopsy]], [[Culture media|culture]], and [[serology]] have been found useful in the diagnosis of [[psittacosis]].


==Treatment==
==Treatment==


===Medical therapy===
===Medical therapy===
Psittacosis is treated with [[tetracyclines]]. Remission of symptoms usually is evident within 48-72 hours. However, relapse can occur, and treatment must continue for at least 10-14 days after [[fever]] abates. For pregnant patients or infants, the preferred treatment is [[azithromycin]] because [[tetracyclines]] are contraindicated.


===Surgery===
===Surgery===
Surgical intervention is not recommended for the management of [[psittacosis]].


===Primary prevention===
===Primary prevention===
Avoid exposure to birds that may carry this [[bacteria]], such as imported parakeets. Medical problems that lead to a [[immunosuppression|weak immune system]] increase the risk for this [[disease]] and should be treated appropriately.
=== Secondary prevention ===
The primary and secondary prevention strategies for [[psittacosis]] are the same.


===Secondary prevention===
==References==
==References==
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{{reflist|2}}
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Latest revision as of 23:51, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

Psittacosis is a zoonotic infectious disease caused by a bacterium called Chlamydophila psittaci (formerly Chlamydia psittaci). The disease is contracted not only from parrots, such as macaws, cockatiels, and budgerigars, but also from pigeons, sparrows, ducks, hens, seagulls, and many other species of birds. The incidence of infection in canaries and finches is believed to be lower than in psittacine birds. As a systemic zoonotic infection with protean clinical features, the major risk factor is exposure to birds. Hence, bird owners, veterinarians, those involved with breeding and selling birds, and commercial poultry processors are most at risk. Patients typically present with 1 week of fevers, headache, myalgias, and a nonproductive cough. Although pneumonia is the most common manifestation, all organ systems can be involved. Serology remains the mainstay of diagnosis; however, polymerase chain reaction techniques offer a rapid and specific alternative. Doxycycline is the treatment of choice.

Historical perspective

The word psittacosis is derived from the Greek work "psittakos," which means parrot. Psittacosis infects psittacines (parrots, parakeets, cockatoos). "Ornithosis" is the term used if it infects other types of birds. It is assumed that the origin of psittacosis is in South America, where the rain forests are populated with many species of psittacine birds. Aboriginal tribes were fond of these birds and used their feathers as parts of their ceremonial clothing. Other psittacine birds were kept as pets in aboriginal villages.

Classification

There is no established classification system for psittacosis.

Pathophysiology

The major risk factor for acquiring psittacosis is exposure to birds. Transmission can occur either by inhalation of aerosolized organisms in form of dried feces or respiratory secretions or by direct contact with birds. The exact molecular details of bacterial uptake are not well understood. It is speculated that chlamydial cell contact is a two-step process: reversible binding followed by irreversible attachment. The key to understanding the pathogenesis of C. psittaci is that frequent and repeated episodes of reinfection are needed for the development of severe disease. Several studies also highlighted the critical importance of host microfilaments, microtubules, and microtubule motor proteins (kinesin and dynein) for uptake and intracellular development of C. psittaci and other Chlamydia spp. As with other intracellular zoonoses such as Q fever and brucellosis, the clinical conditions associated with psittacosis have been seen in many organ systems such as the pulmonary, hepatic, and central nervous systems.

Causes

Psittacosis is caused by the organism Chlamydia psittaci. Chlamydia is understood to be a Gram-negative bacterium belonging to the genus Chlamydia or Chlamydophila in the family Chlamydiaceae. Parachlamydiaceae, Waddliaceae, and Simkaniaceae also belong to the order Chlamydiales, class and phylum Chlamydiae. Chlamydiales are obligate intracellular infectious agents in eukaryotic cells characterized by a unique developmental replication cycle.

Differential diagnosis

Psittacosis must be differentiated from other diseases that cause atypical pneumonia and febrile illness without localizing signs and extrapulmonary manifestations such as gastroenteritis, hepatitis, meningitis, or encephalitis. The three main diseases to differentiate psittacosis from are Chlamydia pneumoniae pneumonia, Mycoplasma pneumoniae pneumonia, and Legionella infection, as they tend to have similar clinical manifestations that can only be differentiated by taking appropriate histories and laboratory investigations. There are other conditions to watch out for which may also present similarly to psittacosis.

Epidemiology and demographics

Since 1996, fewer than 50 confirmed cases of psittacosis have been reported in the United States each year. Many more cases may occur that are not correctly diagnosed or reported. In the United States, the incidence of psittacosis is 0.01 per 100,000 persons. The prevalence and incidence of psittacosis does not vary by gender. There is no racial predilection for psittacosis, as it has been identified in all parts of the world including Africa, China, Europe, and the United States.

Risk factors

Bird owners, pet shop employees, persons who work in poultry processing plants, and veterinarians are at increased risk for contracting psittacosis. Typical birds involved are parrots, parakeets, and budgerigars. Other animals documented with C. psittaci infection include horses, cattle, and koalas, but they have not been documented to transmit the infection to humans.

Screening

According to the USPSTF, there is insufficient evidence to recommend routine screening for psittacosis.

Natural history, complications and prognosis

If left untreated, psittacosis usually presents as flu-like symptoms or an atypical pneumonia. In the first week of psittacosis, the symptoms mimic typhoid fever, including prostrating high fevers, arthralgias, diarrhea, conjunctivitis, epistaxis, and leukopenia. Headache can be so severe that it suggests meningitis and some nuchal rigidity. Towards the end of the first week, stupor or even coma can result in severe cases. The second week is more akin to acute bacteremic pneumococcal pneumonia with continuous high fevers, cough, and dyspnea. Some complications include respiratory failure, acute tubular necrosis, hemolytic anemia, endocarditis, hepatitis, encephalitis and, in some cases, death.

Diagnosis

History and Symptoms

The hallmark of psittacosis is a flu-like reaction with a history of exposure to birds. However, a history of exposure to birds may not always be present. Psittacosis is characterized by a wide range in both disease severity and spectrum of clinical features, but it typically presents with fever, prominent headache, myalgia, and a nonproductive cough. The mainstay of diagnostic testing is serology, although molecular techniques are being increasingly utilized.

Physical Examination

Physical examination findings in a patient with psittacosis include rose spot rashes on the skin called Horder's spots and splenomegaly, which is frequent toward the end of first week. Diagnosis can be suspected in the case of respiratory infection associated with splenomegaly and/or epistaxis.

Laboratory Findings

Exposure history is critical to diagnosis. Complete blood count shows leukopenia, thrombocytopenia, and moderately elevated liver enzymes. Culture of C. psittaci is demanding and requires a level 3 laboratory isolation facility because of the risk of laboratory transmission, so it is rarely performed. Serology is the most widely available method for laboratory diagnosis of C. psittaci infection. Complement fixation, microimmunofluorescence, and EIA are the most commonly used techniques.

Electrocardiogram

There are no electrocardiogram findings associated with psittacosis. However, bradycardia may be noticed on electrocardiogram.

Chest X-Ray

Chest X-rays show lobar consolidation, patchy infiltrates, a diffuse whiteout of the lung field, or pleural effusions.

CT scan

On high resolution CT, infiltrates may be nodular and surrounded by ground glass opacity.

MRI

There are no MRI findings associated with psittacosis.

Echocardiography or ultrasound

There are no echocardiography or ultrasound findings associated with psittacosis.

Other imaging findings

There are no other imaging findings associated with psittacosis.

Other diagnostic studies

Biopsy, culture, and serology have been found useful in the diagnosis of psittacosis.

Treatment

Medical therapy

Psittacosis is treated with tetracyclines. Remission of symptoms usually is evident within 48-72 hours. However, relapse can occur, and treatment must continue for at least 10-14 days after fever abates. For pregnant patients or infants, the preferred treatment is azithromycin because tetracyclines are contraindicated.

Surgery

Surgical intervention is not recommended for the management of psittacosis.

Primary prevention

Avoid exposure to birds that may carry this bacteria, such as imported parakeets. Medical problems that lead to a weak immune system increase the risk for this disease and should be treated appropriately.

Secondary prevention

The primary and secondary prevention strategies for psittacosis are the same.

References


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