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==Overview==
Laboratory findings in HIV-associated nephropathy include: [[proteinuria]], elevated serum [[creatinine]] levels, decreased [[Glomerular filtration rate|GFR]], dyslipidemia, and [[CD4]] counts below 200 cells/mm<sup>3</sup> .<ref name="pmid22248510" /><ref name="pmid21745806" />
 
==Laboratory Findings==
HIV-associated nephropathy (HIVAN) can not be diagnosed clinically or with [[Non-invasive (medical)|noninvasive]] measures such as laboratory findings or ultrasound.<ref name="pmid18588500">{{cite journal| author=Atta MG, Lucas GM, Fine DM| title=HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management. | journal=Expert Rev Anti Infect Ther | year= 2008 | volume= 6 | issue= 3 | pages= 365-71 | pmid=18588500 | doi=10.1586/14787210.6.3.365 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18588500 }} </ref><ref name="pmid16271919">{{cite journal| author=Atta MG, Choi MJ, Longenecker JC, Haymart M, Wu J, Nagajothi N | display-authors=etal| title=Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy. | journal=Am J Med | year= 2005 | volume= 118 | issue= 11 | pages= 1288 | pmid=16271919 | doi=10.1016/j.amjmed.2005.05.027 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16271919 }} </ref><ref name="pmid15154526">{{cite journal| author=Atta MG, Longenecker JC, Fine DM, Nagajothi N, Grover DS, Wu J | display-authors=etal| title=Sonography as a predictor of human immunodeficiency virus-associated nephropathy. | journal=J Ultrasound Med | year= 2004 | volume= 23 | issue= 5 | pages= 603-10; quiz 612-3 | pmid=15154526 | doi=10.7863/jum.2004.23.5.603 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15154526 }} </ref>
 
[[Laboratory]] findings in HIV-associated nephropathy include:<ref name="pmid22248510">{{cite journal| author=Lescure FX, Flateau C, Pacanowski J, Brocheriou I, Rondeau E, Girard PM | display-authors=etal| title=HIV-associated kidney glomerular diseases: changes with time and HAART. | journal=Nephrol Dial Transplant | year= 2012 | volume= 27 | issue= 6 | pages= 2349-55 | pmid=22248510 | doi=10.1093/ndt/gfr676 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22248510  }} </ref><ref name="pmid21745806">{{cite journal| author=Bigé N, Lanternier F, Viard JP, Kamgang P, Daugas E, Elie C | display-authors=etal| title=Presentation of HIV-associated nephropathy and outcome in HAART-treated patients. | journal=Nephrol Dial Transplant | year= 2012 | volume= 27 | issue= 3 | pages= 1114-21 | pmid=21745806 | doi=10.1093/ndt/gfr376 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21745806  }} </ref>
 
* Proteinuria
* Elevated serum [[creatinine]] levels
*Decreased [[Glomerular filtration rate|GFR]]
* Dyslipidemia
*[[CD4]] counts below 200 cells/mm<sup>3</sup>
 
Routine [[laboratory]] tests that may be ordered to help in identify HIV-associated nephropathy (HIVAN) may include:
 
'''Blood Work-up'''
* Complete blood count (CBC)
* Serum [[creatinine]]
*[[Lipid]] profile
*[[Albumin]]
*[[Enzyme linked immunosorbent assay (ELISA)|ELISA]]
*[[Dot blot]]
*[[Latex fixation test|Latex agglutination test]]
*[[Hepatitis B]]
*[[Hepatitis C]]
 
'''Supplemental Test'''
*[[Western blot]]
*[[Immunofluorescence]]
 
'''Urinalysis'''
*[[Proteinuria]]
* Microhematuria
*[[White blood cells|Leukocytes]]
* Oval fat bodies
*[[Hyaline]] casts
 
==References==
==References==
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{{reflist|2}}
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[[Category:Needs content]]
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[[Category:Diseases]]
[[Category:Disease]]
[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Kidney diseases]]
[[Category:Kidney diseases]]
[[Category:HIV/AIDS]]
[[Category:HIV/AIDS]]
[[Category:Immune system disorders]]
[[Category:Immune system disorders]]
[[Category:Infectious disease]]
 
[[category:viral diseases]]
[[Category:Viral diseases]]

Latest revision as of 19:24, 30 June 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3] Shakiba Hassanzadeh, MD[4]

Overview

Laboratory findings in HIV-associated nephropathy include: proteinuria, elevated serum creatinine levels, decreased GFR, dyslipidemia, and CD4 counts below 200 cells/mm3 .[1][2]

Laboratory Findings

HIV-associated nephropathy (HIVAN) can not be diagnosed clinically or with noninvasive measures such as laboratory findings or ultrasound.[3][4][5]

Laboratory findings in HIV-associated nephropathy include:[1][2]

  • Proteinuria
  • Elevated serum creatinine levels
  • Decreased GFR
  • Dyslipidemia
  • CD4 counts below 200 cells/mm3

Routine laboratory tests that may be ordered to help in identify HIV-associated nephropathy (HIVAN) may include:

Blood Work-up

Supplemental Test

Urinalysis

References

  1. ↑ 1.0 1.1 Lescure FX, Flateau C, Pacanowski J, Brocheriou I, Rondeau E, Girard PM; et al. (2012). "HIV-associated kidney glomerular diseases: changes with time and HAART". Nephrol Dial Transplant. 27 (6): 2349–55. doi:10.1093/ndt/gfr676. PMID 22248510.
  2. ↑ 2.0 2.1 Bigé N, Lanternier F, Viard JP, Kamgang P, Daugas E, Elie C; et al. (2012). "Presentation of HIV-associated nephropathy and outcome in HAART-treated patients". Nephrol Dial Transplant. 27 (3): 1114–21. doi:10.1093/ndt/gfr376. PMID 21745806.
  3. ↑ Atta MG, Lucas GM, Fine DM (2008). "HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management". Expert Rev Anti Infect Ther. 6 (3): 365–71. doi:10.1586/14787210.6.3.365. PMID 18588500.
  4. ↑ Atta MG, Choi MJ, Longenecker JC, Haymart M, Wu J, Nagajothi N; et al. (2005). "Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy". Am J Med. 118 (11): 1288. doi:10.1016/j.amjmed.2005.05.027. PMID 16271919.
  5. ↑ Atta MG, Longenecker JC, Fine DM, Nagajothi N, Grover DS, Wu J; et al. (2004). "Sonography as a predictor of human immunodeficiency virus-associated nephropathy". J Ultrasound Med. 23 (5): 603–10, quiz 612-3. doi:10.7863/jum.2004.23.5.603. PMID 15154526.

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