Wild-type (senile) amyloidosis other diagnostic studies: Difference between revisions
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! colspan="2" |Other Diagnostic Studies | ! colspan="2" |Other Diagnostic Studies | ||
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!Histopathological analysis | |||
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* | *[[Endomyocardial biopsy|Endomyocardial biopsy (EMB)]] with [[histopathology]] remains the [[Gold standard (test)|gold standard]] for [[diagnosis]] of cardiac amyloidosis. | ||
* | *[[Histopathology]] demonstrates deposition of amorphous deposits of [[amyloid]] fibrils in the [[heart]]. | ||
* | * The binding of [[Congo red]] [[stain]] to the deposited [[amyloid]] fibrils leads to characteristic apple-green [[birefringence]] under polarized [[light microscopy]] and an intense yellow-green [[fluorescence]] is seen when binding to [[thioflavin]]. | ||
* | * Precursor [[protein]] identification can be accomplished by [[immunohistochemistry]], [[Electron microscope|electron microscopy]], or [[mass spectrometry]] (preferred), depending upon institutional expertise. | ||
* | * Adjunctive [[laboratory]] [[Test|tests]] to rule out AL include assaying for other [[Organ (anatomy)|organ]] dysfunction (e.g., [[proteinuria]], [[alkaline phosphatase]]) and directly measuring the circulating [[Light chain|light chains]] in [[Blood plasma|plasma]]. | ||
*[[Endomyocardial biopsy|EMB]] is associated with risks of [[Complication (medicine)|complications]] such as: | |||
**[[Ventricle (heart)|Ventricular]] free-wall [[perforation]] | |||
**[[Cardiac arrhythmia|Arrhythmia]] | |||
**[[Electrical conduction system of the heart|Conduction]] abnormalities | |||
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!Genetic testing | |||
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* | *[[DNA]] sequencing for the [[transthyretin]] [[gene]] | ||
* Absence of [[amino acid]] sequence abnormalities by [[mass spectrometry]] is consistent with wild-type (senile) amyloidosis | |||
* Presence of a [[Pathology|pathologic]] [[mutation]] | |||
** Predict sites of [[Organ (anatomy)|organ]] involvement | |||
**[[Family history]] | |||
* Absence of amino acid sequence abnormalities by mass spectrometry is consistent with | |||
* Presence of a pathologic mutation | |||
** Predict sites of organ involvement | |||
** Family history | |||
|} | |} | ||
Latest revision as of 19:13, 20 December 2019
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Wild-type (senile) amyloidosis Microchapters |
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Differentiating Wild-type (senile) amyloidosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Other diagnostic studies that help in diagnosing wild-type (senile) amyloidosis include histopathological analysis and genetic testing.
Other Diagnostic Studies
Other diagnostic studies that help in diagnosing wild-type (senile) amyloidosis include histopathological analysis and genetic testing.[1]
| Other Diagnostic Studies | |
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| Histopathological analysis |
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| Genetic testing |
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References
- ↑ Damy T, Deux JF, Moutereau S, Guendouz S, Mohty D, Rappeneau S, Guellich A, Hittinger L, Loric S, Lefaucheur JP, Plante-Bordeneuve V (December 2013). "Role of natriuretic peptide to predict cardiac abnormalities in patients with hereditary transthyretin amyloidosis". Amyloid. 20 (4): 212–20. doi:10.3109/13506129.2013.825240. PMID 23964755.