Atypical teratoid rhabdoid tumor laboratory findings: Difference between revisions

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{{Atypical teratoid rhabdoid tumor}}
{{CMG}}{{AE}}{{SR}}


{{Atypical teratoid rhabdoid tumor}}
{{CMG}}
==Overview==
==Overview==
[[CSF analysis]] is done to detect any [[leptomeningeal]] dissemination with involvement of the [[cerebrospinal fluid]]. Large [[tumor]] [[Cell (biology)|cells]], eccentricity of the [[Cell nucleus|nuclei]], and prominent [[Nucleolus|nucleoli]] are the consistent findings.
==Laboratory Findings==
==Laboratory Findings==
; [[Lumbar Puncture]]
===Lumbar Puncture===
Examination of the [[cerebrospinal fluid]] is important as one-third of patients will have intracranial  dissemination with involvement of the cerebrospinal fluid (CSF). Large tumor cells, eccentricity of the nuclei and prominent nucleoli are consistent findings.<ref>{{cite journal
* [[CSF analysis]] is done to detect any [[leptomeningeal]] dissemination with involvement of the [[cerebrospinal fluid]]. Large [[tumor]] [[Cell (biology)|cells]], eccentricity of the [[Cell nucleus|nuclei]], and prominent [[Nucleolus|nucleoli]] are consistent findings.<ref name="lab1atrt">{{cite journal|author=Lu L, Wilkinson EJ, Yachnis AT|title=CSF cytology of atypical teratoid/rhabdoid tumor of the brain in a two-year-old girl: a case report|journal=Diagn. Cytopathol.|volume=23|issue=5|pages=329–32|year=2000|pmid=11074628}}</ref>
|author=Lu L, Wilkinson EJ, Yachnis AT
|title=CSF cytology of atypical teratoid/rhabdoid tumor of the brain in a two-year-old girl: a case report
|journal=Diagn. Cytopathol.
|volume=23
|issue=5
|pages=329–32
|year=2000
|pmid=11074628
}}</ref>


==Immunohistochemistry==
==References==
{{reflist|1}}


[[Immunohistochemistry]] refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies binding specifically to antigens in biological tissues.  A tissue sample is stained to identify specific cellular proteins.  Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. Immunohistochemistry is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue.  Below are proteins found in an Atypical Teratoid Rhaboid Tumor.
*[[Vimentin]]-positive
*[[Cytokeratin]]-positive
*Neuron specific enolase-positive
*Epitelial membrane antigen-positive
*[[Glial fibrillary acidic protein]]- positive
*[[Synaptophysin]]
*[[Chromogranin]]
*Smooth muscle [[actin]]
*[[Desmin]]
*Carcinoembrionary [[antigen]]
*CD99
*[[S-100 protein|S-100]]
*[[neurofilament]]s
*[[Alpha-fetoprotein|AFP]]- not found
*[[Human chorionic gonadotropin|HCG]] – negative
==References==
{{reflist|2}}
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[[Category:Oncology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Rare cancers]]
[[Category:Rare cancers]]
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[[Category:Pediatric cancers]]
[[Category:Pediatric cancers]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Needs content]]
[[Category:Oncology]]
 
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Latest revision as of 19:47, 16 May 2019

Atypical teratoid rhabdoid tumor Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

CSF analysis is done to detect any leptomeningeal dissemination with involvement of the cerebrospinal fluid. Large tumor cells, eccentricity of the nuclei, and prominent nucleoli are the consistent findings.

Laboratory Findings

Lumbar Puncture

References

  1. Lu L, Wilkinson EJ, Yachnis AT (2000). "CSF cytology of atypical teratoid/rhabdoid tumor of the brain in a two-year-old girl: a case report". Diagn. Cytopathol. 23 (5): 329–32. PMID 11074628.

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