Hereditary nonpolyposis colorectal cancer natural history: Difference between revisions
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{{Hereditary nonpolyposis colorectal cancer}} | {{Hereditary nonpolyposis colorectal cancer}} | ||
{{CMG}} | {{CMG}}{{AE}}{{MV}} | ||
==Overview== | ==Overview== | ||
If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel [[Organ (anatomy)|organ]] [[cancer]] or [[metastasis]]. Hereditary nonpolyposis colorectal cancer is an aggressive [[syndrome]] characterized by early onset of [[cancer]]. Affected [[Organ (anatomy)|organs]] include [[endometrium]] (second most common after [[Colon (anatomy)|colon]]), [[ovary]], [[stomach]], [[small intestine]], [[hepatobiliary tract]], upper [[urinary tract]], [[brain]], and [[skin]]. [[Complication (medicine)|Complications]] of hereditary nonpolyposis colorectal cancer are usually related to the [[surgery]]. The 5-year relative survival of [[Patient|patients]] with hereditary nonpolyposis colorectal cancer is approximately 79.3%. A feature associated with worse [[prognosis]] is late stage [[diagnosis]]. | |||
==Natural History, Complications, and Prognosis== | |||
=== Natural History === | |||
* If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel [[Organ (anatomy)|organ]] [[Cancer|cancers]] or [[metastasis]]. | |||
*Other [[Organ (anatomy)|organ]] [[Cancer|cancers]] include:<ref name="radio">Hereditary nonpolyposis colorectal cancer. Dr Amir Rezaee. Radiopedia. http://radiopaedia.org/articles/hereditary-non-polyposis-colorectal-cancer-1 Accessed on December 3, 2015</ref> | |||
:* [[Genitourinary tract]] [[Cancer|malignancies]] | |||
:* [[Endometrial cancer|Endometrial carcinoma]]: 30 - 50% lifetime risk | |||
:* [[Ovarian cancer|Ovarian tumors]] | |||
:* [[Urinary system|Urinary tract]] [[cancer]] | |||
:* [[Small bowel]] [[cancer]]: lifetime risk ~5% | |||
:* [[Duodenum]] 45% | |||
:* [[Jejunum]] 29% | |||
:* [[Ileum]] 12% | |||
:* Not specified 14% | |||
:* [[Stomach cancer|Gastric cancer]] | |||
:* [[CNS]] [[Tumor|tumors]] ([[Glioblastoma multiforme|glioblastoma]]) | |||
* More advanced stages are characterized by multiple [[Organ (anatomy)|organ]] [[metastasis]]. | |||
===Prognosis=== | |||
*The 5-year relative survival of [[Patient|patients]] with hereditary nonpolyposis colorectal cancer is approximately 79.3%.<ref name="pmid10348829">{{cite journal |vauthors=Vasen HF, Watson P, Mecklin JP, Lynch HT |title=New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC |journal=Gastroenterology |volume=116 |issue=6 |pages=1453–6 |year=1999 |pmid=10348829 |doi= |url=}}</ref> | |||
===Complications=== | |||
*[[Complication (medicine)|Complications]] that can develop as a result of hereditary nonpolyposis colorectal cancer are sentinel [[Organ (anatomy)|organ]] [[Tumor|tumors]], such as: | |||
:*[[Endometrial cancer]]. | |||
:*[[Gastric cancer]] | |||
:*[[Ovarian cancer]] | |||
:*[[Urinary system|Urinary tract]] [[cancers]] | |||
:*[[Small bowel]] [[Cancer|cancers]] | |||
:*[[Central nervous system]] [[Tumor|tumors]] | |||
*Other [[Complication (medicine)|complications]] of hereditary nonpolyposis colorectal cancer are usually related to the [[colorectal surgery]]. | |||
==References== | ==References== | ||
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[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
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Latest revision as of 14:56, 30 April 2019
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Hereditary Nonpolyposis Colorectal Cancer Microchapters |
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Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel organ cancer or metastasis. Hereditary nonpolyposis colorectal cancer is an aggressive syndrome characterized by early onset of cancer. Affected organs include endometrium (second most common after colon), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. Complications of hereditary nonpolyposis colorectal cancer are usually related to the surgery. The 5-year relative survival of patients with hereditary nonpolyposis colorectal cancer is approximately 79.3%. A feature associated with worse prognosis is late stage diagnosis.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel organ cancers or metastasis.
- Other organ cancers include:[1]
- Genitourinary tract malignancies
- Endometrial carcinoma: 30 - 50% lifetime risk
- Ovarian tumors
- Urinary tract cancer
- Small bowel cancer: lifetime risk ~5%
- Duodenum 45%
- Jejunum 29%
- Ileum 12%
- Not specified 14%
- Gastric cancer
- CNS tumors (glioblastoma)
- More advanced stages are characterized by multiple organ metastasis.
Prognosis
- The 5-year relative survival of patients with hereditary nonpolyposis colorectal cancer is approximately 79.3%.[2]
Complications
- Complications that can develop as a result of hereditary nonpolyposis colorectal cancer are sentinel organ tumors, such as:
- Other complications of hereditary nonpolyposis colorectal cancer are usually related to the colorectal surgery.
References
- ↑ Hereditary nonpolyposis colorectal cancer. Dr Amir Rezaee. Radiopedia. http://radiopaedia.org/articles/hereditary-non-polyposis-colorectal-cancer-1 Accessed on December 3, 2015
- ↑ Vasen HF, Watson P, Mecklin JP, Lynch HT (1999). "New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC". Gastroenterology. 116 (6): 1453–6. PMID 10348829.