HIST1H2BD: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Todrobbins
(Added free to read link in citations with OAbot #oabot)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Histone H2B type 1-D''' is a [[protein]] that in humans is encoded by the ''HIST1H2BD'' [[gene]].<ref name="pmid1916825">{{cite journal |vauthors=Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D | title = Isolation and characterization of two human H1 histone genes within clusters of core histone genes | journal = Genomics | volume = 10 | issue = 4 | pages = 940–8 |date=Nov 1991 | pmid = 1916825 | pmc =  | doi =10.1016/0888-7543(91)90183-F }}</ref><ref name="pmid12408966">{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc = | doi =10.1016/S0888-7543(02)96850-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BD histone cluster 1, H2bd| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3017| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HIST1H2BD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1f66}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1u35}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = Histone cluster 1, H2bd
| HGNCid = 4747
| Symbol = HIST1H2BD
| AltSymbols =; H2B.1B; H2B/b; H2BFB; HIRIP2; MGC90432; dJ221C16.6
| OMIM = 602799
| ECnumber =
| Homologene = 87009
| MGIid = 2448409
  | GeneAtlas_image1 = PBB_GE_HIST1H2BD_222067_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}  
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3017
    | Hs_Ensembl = ENSG00000158373
    | Hs_RefseqProtein = NP_066407
    | Hs_RefseqmRNA = NM_021063
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 26266328
    | Hs_GenLoc_end = 26279553
    | Hs_Uniprot = P58876
    | Mm_EntrezGene = 319188
    | Mm_Ensembl = ENSMUSG00000069308
    | Mm_RefseqmRNA = NM_178202
    | Mm_RefseqProtein = NP_835509
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 21794953
    | Mm_GenLoc_end = 21796675
    | Mm_Uniprot = Q8CGP2
  }}
}}
'''Histone cluster 1, H2bd''', also known as '''HIST1H2BD''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BD histone cluster 1, H2bd| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3017| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BD histone cluster 1, H2bd| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3017| accessdate = }}</ref>
| summary_text = Histones are basic [[nuclear proteins]] that are responsible for the nucleosome structure of the chromosomal fiber in [[eukaryote]]. [[Nucleosomes]] consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The [[chromatin]] fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Albig W, Kardalinou E, Drabent B, ''et al.'' |title=Isolation and characterization of two human H1 histone genes within clusters of core histone genes. |journal=Genomics |volume=10 |issue= 4 |pages= 940-8 |year= 1991 |pmid= 1916825 |doi=  }}
*{{cite journal  | author=Albig W |title=Human histone gene organization: nonregular arrangement within a large cluster |journal=Genomics |volume=40 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 |name-list-format=vanc| author2=Kioschis P | author3=Poustka A | display-authors=3  | last4=Meergans  | first4=Konstanze  | last5=Doenecke  | first5=Detlef }}
*{{cite journal  | author=Albig W, Kioschis P, Poustka A, ''et al.'' |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314-22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
*{{cite journal  |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 }}
*{{cite journal  | author=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus. |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284-94 |year= 1998 |pmid= 9439656 |doi=  }}
*{{cite journal  |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
*{{cite journal  | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535-44 |year= 1998 |pmid= 9566873 |doi=  }}
*{{cite journal  | author=Lorain S |title=Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546–56 |year= 1998 |pmid= 9710638 |doi=  | pmc=109139 |name-list-format=vanc| author2=Quivy JP  | author3=Monier-Gavelle F  | display-authors=3  | last4=Scamps  | first4=C  | last5=Lécluse  | first5=Y  | last6=Almouzni  | first6=G  | last7=Lipinski  | first7=M  }}
*{{cite journal  | author=Lorain S, Quivy JP, Monier-Gavelle F, ''et al.'' |title=Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546-56 |year= 1998 |pmid= 9710638 |doi=  }}
*{{cite journal  | author=Deng L |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593  |name-list-format=vanc| author2=de la Fuente C | author3=Fu P | display-authors=3  | last4=Wang  | first4=L  | last5=Donnelly  | first5=R  | last6=Wade  | first6=JD  | last7=Lambert | first7=P  | last8=Li  | first8=H  | last9=Lee  | first9=CG }}
*{{cite journal | author=Deng L, de la Fuente C, Fu P, ''et al.'' |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278-95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal  | author=Deng L |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 |name-list-format=vanc| author2=Wang D  | author3=de la Fuente C  | display-authors=3  | last4=Wang  | first4=L  | last5=Li  | first5=H  | last6=Lee | first6=CG | last7=Donnelly  | first7=R  | last8=Wade  | first8=JD  | last9=Lambert  | first9=P }}
*{{cite journal  | author=Deng L, Wang D, de la Fuente C, ''et al.'' |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312-26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Marzluff WF, Gongidi P, Woods KR, ''et al.'' |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487-98 |year= 2003 |pmid= 12408966 |doi=  }}
*{{cite journal  | author=Cheung WL |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase |journal=Cell |volume=113 |issue= 4 |pages= 507–17 |year= 2003 |pmid= 12757711 |doi=10.1016/S0092-8674(03)00355-6  |name-list-format=vanc| author2=Ajiro K | author3=Samejima K  | display-authors=3  | last4=Kloc  | first4=Malgorzata  | last5=Cheung  | first5=Peter  | last6=Mizzen  | first6=Craig A.  | last7=Beeser  | first7=Alexander  | last8=Etkin  | first8=Laurence D. | last9=Chernoff  | first9=Jonathan  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |name-list-format=vanc| author2=Palmer SA  | author3=Sims SK  | display-authors=3  | last4=Edwards  | first4=C. A.  | last5=Ashurst  | first5=J. L.  | last6=Wilming  | first6=L.  | last7=Jones  | first7=M. C. | last8=Horton  | first8=R. | last9=Hunt  | first9=S. E. }}
*{{cite journal | author=Cheung WL, Ajiro K, Samejima K, ''et al.'' |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. |journal=Cell |volume=113 |issue= 4 |pages= 507-17 |year= 2003 |pmid= 12757711 |doi=  }}
*{{cite journal  |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631  | pmc=291826 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550-61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Golebiowski F, Kasprzak KS |title=Inhibition of core histones acetylation by carcinogenic nickel(II) |journal=Mol. Cell. Biochem. |volume=279 |issue= 1–2 |pages= 133–9 |year= 2007 |pmid= 16283522 |doi= 10.1007/s11010-005-8285-1 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Zhu B |title=Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation |journal=Mol. Cell |volume=20 |issue= 4 |pages= 601–11 |year= 2006 |pmid= 16307923 |doi= 10.1016/j.molcel.2005.09.025  |name-list-format=vanc| author2=Zheng Y  | author3=Pham AD  | display-authors=3  | last4=Mandal  | first4=Subhrangsu S.  | last5=Erdjument-Bromage  | first5=Hediye  | last6=Tempst  | first6=Paul  | last7=Reinberg  | first7=Danny }}
*{{cite journal  | author=Golebiowski F, Kasprzak KS |title=Inhibition of core histones acetylation by carcinogenic nickel(II). |journal=Mol. Cell. Biochem. |volume=279 |issue= 1-2 |pages= 133-9 |year= 2007 |pmid= 16283522 |doi= 10.1007/s11010-005-8285-1 }}
*{{cite journal  | author=Bonenfant D |title=Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry |journal=Mol. Cell. Proteomics |volume=5 |issue= 3 |pages= 541–52 |year= 2006 |pmid= 16319397 |doi= 10.1074/mcp.M500288-MCP200  |name-list-format=vanc| author2=Coulot M  | author3=Towbin H  | display-authors=3  | last4=Schindler  | first4=P  | last5=Van Oostrum  | first5=J |url=http://www.mcponline.org/content/5/3/541.full.pdf}}
*{{cite journal | author=Zhu B, Zheng Y, Pham AD, ''et al.'' |title=Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. |journal=Mol. Cell |volume=20 |issue= 4 |pages= 601-11 |year= 2006 |pmid= 16307923 |doi= 10.1016/j.molcel.2005.09.025 }}
*{{cite journal  | author=Siuti N |title=Gene-specific characterization of human histone H2B by electron capture dissociation |journal=J. Proteome Res. |volume=5 |issue= 2 |pages= 233–9 |year= 2006 |pmid= 16457587 |doi= 10.1021/pr050268v  |name-list-format=vanc| author2=Roth MJ  | author3=Mizzen CA  | display-authors=3  | last4=Kelleher  | first4=Neil L.  | last5=Pesavento  | first5=James J. }}
*{{cite journal  | author=Bonenfant D, Coulot M, Towbin H, ''et al.'' |title=Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. |journal=Mol. Cell Proteomics |volume=5 |issue= 3 |pages= 541-52 |year= 2006 |pmid= 16319397 |doi= 10.1074/mcp.M500288-MCP200 }}
*{{cite journal  | author=Beck HC |title=Quantitative proteomic analysis of post-translational modifications of human histones |journal=Mol. Cell. Proteomics |volume=5 |issue= 7 |pages= 1314–25 |year= 2006 |pmid= 16627869 |doi= 10.1074/mcp.M600007-MCP200  |name-list-format=vanc| author2=Nielsen EC  | author3=Matthiesen R  | display-authors=3  | last4=Jensen  | first4=LH  | last5=Sehested  | first5=M  | last6=Finn  | first6=P  | last7=Grauslund  | first7=M  | last8=Hansen  | first8=AM  | last9=Jensen  | first9=ON }}
*{{cite journal | author=Siuti N, Roth MJ, Mizzen CA, ''et al.'' |title=Gene-specific characterization of human histone H2B by electron capture dissociation. |journal=J. Proteome Res. |volume=5 |issue= 2 |pages= 233-9 |year= 2006 |pmid= 16457587 |doi= 10.1021/pr050268v }}
*{{cite journal  | author=Pavri R |title=Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II |journal=Cell |volume=125 |issue= 4 |pages= 703–17 |year= 2006 |pmid= 16713563 |doi= 10.1016/j.cell.2006.04.029 |name-list-format=vanc| author2=Zhu B  | author3=Li G  | display-authors=3  | last4=Trojer  | first4=Patrick  | last5=Mandal  | first5=Subhrangsu  | last6=Shilatifard  | first6=Ali  | last7=Reinberg  | first7=Danny }}
*{{cite journal | author=Beck HC, Nielsen EC, Matthiesen R, ''et al.'' |title=Quantitative proteomic analysis of post-translational modifications of human histones. |journal=Mol. Cell Proteomics |volume=5 |issue= 7 |pages= 1314-25 |year= 2006 |pmid= 16627869 |doi= 10.1074/mcp.M600007-MCP200 }}
*{{cite journal | author=Pavri R, Zhu B, Li G, ''et al.'' |title=Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. |journal=Cell |volume=125 |issue= 4 |pages= 703-17 |year= 2006 |pmid= 16713563 |doi= 10.1016/j.cell.2006.04.029 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3017}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-6-stub}}
{{WikiDoc Sources}}

Latest revision as of 14:48, 5 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.[3]

References

  1. ↑ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  2. ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  3. ↑ 3.0 3.1 "Entrez Gene: HIST1H2BD histone cluster 1, H2bd".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=HIST1H2BD&oldid=1533398"