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{{Infobox_gene}}
{{Infobox_gene}}
'''Poly(U)-binding-splicing factor PUF60''' is a [[protein]] that in humans is encoded by the ''PUF60'' [[gene]].<ref name="pmid10668799">{{cite journal | vauthors = Bouffard P, Barbar E, Briere F, Boire G | title = Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins | journal = RNA | volume = 6 | issue = 1 | pages = 66–78 |date=Feb 2000 | pmid = 10668799 | pmc = 1369894 | doi =10.1017/S1355838200990277  }}</ref><ref name="pmid10882074">{{cite journal | vauthors = Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D | title = The FBP interacting repressor targets TFIIH to inhibit activated transcription | journal = Mol Cell | volume = 5 | issue = 2 | pages = 331–41 |date=Jul 2000 | pmid = 10882074 | pmc =  | doi =10.1016/S1097-2765(00)80428-1  }}</ref><ref name="pmid17579712">{{cite journal | vauthors = Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR | title = Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65 | journal = PLoS ONE | volume = 2 | issue = 6 | pages = e538 |date=Jun 2007 | pmid = 17579712 | pmc = 1888729 | doi = 10.1371/journal.pone.0000538 | editor1-last = Valcarcel | editor1-first = Juan }} {{open access}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22827| accessdate = }}</ref>
'''Poly(U)-binding-splicing factor PUF60''' is a [[protein]] that in humans is encoded by the ''PUF60'' [[gene]].<ref name="pmid10668799">{{cite journal | vauthors = Bouffard P, Barbar E, Briere F, Boire G | title = Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins | journal = RNA | volume = 6 | issue = 1 | pages = 66–78 |date=Feb 2000 | pmid = 10668799 | pmc = 1369894 | doi =10.1017/S1355838200990277  }}</ref><ref name="pmid10882074">{{cite journal | vauthors = Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D | title = The FBP interacting repressor targets TFIIH to inhibit activated transcription | journal = Mol Cell | volume = 5 | issue = 2 | pages = 331–41 |date=Jul 2000 | pmid = 10882074 | pmc =  | doi =10.1016/S1097-2765(00)80428-1  }}</ref><ref name="pmid17579712">{{cite journal | vauthors = Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR | title = Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65 | journal = PLoS ONE | volume = 2 | issue = 6 | pages = e538 |date=Jun 2007 | pmid = 17579712 | pmc = 1888729 | doi = 10.1371/journal.pone.0000538 | editor1-last = Valcarcel | editor1-first = Juan | bibcode = 2007PLoSO...2..538H }} {{open access}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22827| accessdate = }}</ref>


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==Interactions==
==Interactions==
PUF60 has been shown to [[Protein-protein interaction|interact]] with [[U2AF2]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=Oct 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | format = | laysummary = | laysource = | laydate = }}</ref><ref name=pmid17353931>{{cite journal |last=Ewing |first=Rob M |authorlink= |author2=Chu Peter |author3=Elisma Fred |author4=Li Hongyan |author5=Taylor Paul |author6=Climie Shane |author7=McBroom-Cerajewski Linda |author8=Robinson Mark D |author9=O'Connor Liam |author10=Li Michael |author11=Taylor Rod |author12=Dharsee Moyez |author13= Ho Yuen |author14=Heilbut Adrian |author15=Moore Lynda |author16=Zhang Shudong |author17=Ornatsky Olga |author18=Bukhman Yury V |author19=Ethier Martin |author20=Sheng Yinglun |author21=Vasilescu Julian |author22=Abu-Farha Mohamed |author23=Lambert Jean-Philippe |author24=Duewel Henry S |author25=Stewart Ian I |author26=Kuehl Bonnie |author27=Hogue Kelly |author28=Colwill Karen |author29=Gladwish Katharine |author30=Muskat Brenda |author31=Kinach Robert |author32=Adams Sally-Lin |author33=Moran Michael F |author34=Morin Gregg B |author35=Topaloglou Thodoros |author36=Figeys Daniel |year=2007|title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages=89 |publisher= |location = England| issn = | pmid = 17353931 |doi = 10.1038/msb4100134 | bibcode = | oclc =| id = | url = | format = | accessdate = | laysummary = | laysource = | laydate = |pmc=1847948 }}</ref>
PUF60 has been shown to [[Protein-protein interaction|interact]] with [[U2AF2]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=Oct 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode =2005Natur.437.1173R | oclc =| id = | url = | format = | laysummary = | laysource = | laydate = }}</ref><ref name=pmid17353931>{{cite journal |last=Ewing |first=Rob M |authorlink= |author2=Chu Peter |author3=Elisma Fred |author4=Li Hongyan |author5=Taylor Paul |author6=Climie Shane |author7=McBroom-Cerajewski Linda |author8=Robinson Mark D |author9=O'Connor Liam |author10=Li Michael |author11=Taylor Rod |author12=Dharsee Moyez |author13= Ho Yuen |author14=Heilbut Adrian |author15=Moore Lynda |author16=Zhang Shudong |author17=Ornatsky Olga |author18=Bukhman Yury V |author19=Ethier Martin |author20=Sheng Yinglun |author21=Vasilescu Julian |author22=Abu-Farha Mohamed |author23=Lambert Jean-Philippe |author24=Duewel Henry S |author25=Stewart Ian I |author26=Kuehl Bonnie |author27=Hogue Kelly |author28=Colwill Karen |author29=Gladwish Katharine |author30=Muskat Brenda |author31=Kinach Robert |author32=Adams Sally-Lin |author33=Moran Michael F |author34=Morin Gregg B |author35=Topaloglou Thodoros |author36=Figeys Daniel |year=2007|title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages=89 |publisher= |location = England| issn = | pmid = 17353931 |doi = 10.1038/msb4100134 | bibcode = | oclc =| id = | url = | format = | accessdate = | laysummary = | laysource = | laydate = |pmc=1847948 }}</ref>


==References==
==References==
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*{{cite journal  |vauthors=Liu J, Akoulitchev S, Weber A, etal |title=Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum |journal=Cell |volume=104 |issue= 3 |pages= 353–63 |year= 2001 |pmid= 11239393 |doi=10.1016/S0092-8674(01)00223-9  }}
*{{cite journal  |vauthors=Liu J, Akoulitchev S, Weber A, etal |title=Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum |journal=Cell |volume=104 |issue= 3 |pages= 353–63 |year= 2001 |pmid= 11239393 |doi=10.1016/S0092-8674(01)00223-9  }}
*{{cite journal  | vauthors=Sandrock B, Egly JM |title=A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35328–33 |year= 2001 |pmid= 11445587 |doi= 10.1074/jbc.M105570200 }}
*{{cite journal  | vauthors=Sandrock B, Egly JM |title=A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35328–33 |year= 2001 |pmid= 11445587 |doi= 10.1074/jbc.M105570200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal  |vauthors=Liu J, Kouzine F, Nie Z, etal |title=The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression |journal=EMBO J. |volume=25 |issue= 10 |pages= 2119–30 |year= 2006 |pmid= 16628215 |doi= 10.1038/sj.emboj.7601101  | pmc=1462968 }}
*{{cite journal  |vauthors=Liu J, Kouzine F, Nie Z, etal |title=The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression |journal=EMBO J. |volume=25 |issue= 10 |pages= 2119–30 |year= 2006 |pmid= 16628215 |doi= 10.1038/sj.emboj.7601101  | pmc=1462968 }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}

Latest revision as of 08:44, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.[1][2][3][4]

The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.[4]

Interactions

PUF60 has been shown to interact with U2AF2.[5][6]

References

  1. ↑ Bouffard P, Barbar E, Briere F, Boire G (Feb 2000). "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins". RNA. 6 (1): 66–78. doi:10.1017/S1355838200990277. PMC 1369894. PMID 10668799.
  2. ↑ Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D (Jul 2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
  3. ↑ Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (Jun 2007). Valcarcel J, ed. "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65". PLoS ONE. 2 (6): e538. Bibcode:2007PLoSO...2..538H. doi:10.1371/journal.pone.0000538. PMC 1888729. PMID 17579712. open access publication – free to read
  4. ↑ 4.0 4.1 "Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor".
  5. ↑ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  6. ↑ Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading



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