Polycystic kidney disease: Difference between revisions

	Polycystic kidney disease Microchapters
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Latest revision as of 15:30, 25 July 2018

For patient information page, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2], Serge Korjian, Yazan Daaboul

Synonyms and keywords: Polycystic kidney syndrome; polycystic kidney; PKD; autosomal dominant polycystic kisney disease; ADPKD; autosomal recessive polycystic kidney disease; ARPKD

Overview

Historical perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Differentiating Polycystic kidney disease from Other Diseases

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Future or Investigational Therapies

Case Studies

Case #1

External links

http://www.ncbi.nlm.nih.gov/disease/PKD.html

Template:Cystic diseases

Template:WH Template:WS

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{DiseaseDisorder infobox |
-  Name           = Polycystic Kidney Disease |
-  ICD10          = {{ICD10|Q|61||q|60}} |
-  ICD9           = {{ICD9|753.1}} |
-  ICDO           = |
-  Image          = Polycystic kidneys, gross pathology 20G0027 lores.jpg |
-  Caption        = Polycystic kidneys |
-  OMIM           = 173900 |
-  MedlinePlus    = 000502 |
-  DiseasesDB     = 10262 |
-  DiseasesDB_mult= {{DiseasesDB2|10280}} |
-  MeshID         = D007690 |
-}}
 {{Polycystic kidney disease}}
-'''For patient information page, click [[{{PAGENAME}} (patient information)|here]]
+'''For patient information page, click [[{{PAGENAME}} (patient information)|here]]'''
-{{CMG}}; {{AE}}  [[User:zorkun|Cafer Zorkun]] M.D., PhD.
+{{CMG}}; {{AE}} {{MKA}}, [[User:Sergekorjian|Serge Korjian]], [[User:YazanDaaboul| Yazan Daaboul]]
-{{SK}} Polycystic kidney syndrome; polycystic kidney; PKD
+{{SK}} Polycystic kidney syndrome; polycystic kidney; PKD; autosomal dominant polycystic kisney disease; ADPKD; autosomal recessive polycystic kidney disease; ARPKD
 ==[[Polycystic kidney disease overview|Overview]]==
+==[[Polycystic kidney disease historical perspective|Historical perspective]]==
+==[[Polycystic kidney disease classification|Classification]]==
 ==[[Polycystic kidney disease pathophysiology|Pathophysiology]]==
-==[[Polycystic kidney disease epidemiology and demographics|Epidemiology & Demographics]]==
+==[[Polycystic kidney disease causes|Causes]]==
-==[[Polycystic kidney disease differential diagnosis|Differentiating Polycystic kidney disease from Other Diseases]]==
+==[[Polycystic kidney disease epidemiology and demographics|Epidemiology and Demographics]]==
-==[[Polycystic kidney disease natural history|Natural History, Complications & Prognosis]]==
+==[[Polycystic kidney disease differentiating polycystic kidney disease from other diseases|Differentiating Polycystic kidney disease from Other Diseases]]==
-==Diagnosis==
+==[[Polycystic kidney disease risk factor|Risk Factors]]==
-A definite diagnosis of ADPKD relies on imaging or molecular [[genetic testing]]. The sensitivity of testing is nearly 100% for all patients with ADPKD who are age 30 years or older and for younger patients with PKD1 mutations; these criteria are only 67% sensitive for patients with PKD2 mutations who are younger than age 30 years. Large [[echogenic]] kidneys without distinct macroscopic cysts in an infant/child at 50% risk for ADPKD are diagnostic. In the absence of a family history of ADPKD, the presence of bilateral renal enlargement and cysts, with or without the presence of [[hepatic]] cysts, and the absence of other manifestations suggestive of a different renal cystic disease provide presumptive, but not definite, evidence for the diagnosis.
+==[[Polycystic kidney disease screening|Screening]]==
-Molecular [[genetic testing]] by [[linkage analysis]] or direct mutation screening is available clinically; however, genetic heterogeneity is a significant complication to molecular genetic testing. Sometimes a relatively large number of affected family members need to be tested in order to establish which one of the two possible genes is responsible within each family. The large size and complexity of PKD1 and PKD2 [[gene]]s, as well as marked allelic heterogeneity, present obstacles to molecular testing by direct DNA analysis. In the research setting, [[mutation]] detection rates of 50-75% have been obtained for  PKD1 and ~75% for  PKD2. Clinical testing of the  PKD1 and  PKD2 genes by direct [[sequence analysis]] is now available, with a detection rate for disease-causing mutations of 50-70%.
-[[Genetic counseling]] may be helpful for families at risk for polycystic kidney disease.
+==[[Polycystic kidney disease natural history|Natural History, Complications and Prognosis]]==
-===Adult type Polycystic kidney disease===
+==[[Polycystic kidney disease diagnosis|Diagnosis]]==
+[[Polycystic kidney disease diagnostic study of choice|Diagnostic Study of Choice]] | [[Polycystic kidney disease history and symptoms|History and Symptoms]] | [[Polycystic kidney disease physical examination|Physical Examination]] | [[Polycystic kidney disease laboratory findings|Laboratory Findings]] | [[Polycystic kidney disease electrocardiogram|Electrocardiogram]] | [[Polycystic kidney disease CT|CT]] | [[Polycystic kidney disease MRI|MRI]] | [[Polycystic kidney disease ultrasound|Ultrasound]] | [[Polycystic kidney disease other imaging findings|Other Imaging Findings]] | [[Polycystic kidney disease other diagnostic studies|Other Diagnostic Studies]]
-<youtube v=6Ws9cfsjZIk/>
+==[[Polycystic kidney disease treatment|Treatment]]==
+:[[Polycystic kidney disease medical therapy|Medical Therapy]] | [[Polycystic kidney disease surgery|Surgery]] | [[Polycystic kidney disease primary prevention|Primary Prevention]] | [[Polycystic kidney disease secondary prevention|Secondary Prevention]] | [[Polycystic kidney disease future or investigational therapies|Future or Investigational Therapies]]
-==Resources==
+==Case Studies==
-The [http://www.pkdcure.org PKD Foundation] is the only non-profit organization worldwide dedicated solely to PKD research.
+[[Polycystic kidney disease case study one|Case #1]]
-Parent of two children with ARPKD blog: www.kidneysandeyes.com
 ==External links==
 *http://www.ncbi.nlm.nih.gov/disease/PKD.html
 {{Congenital malformations of genital organs and urinary system}}
@@ Line 57: / Line 47: @@
 [[Category:Urology]]
 [[Category:Channelopathy]]
+[[Category:Disease]]
 {{WH}}
 {{WS}}

v t e Congenital malformations and deformations of sex organs (Q50-Q56 · 752)
Female	Template:Navbox subgroup
Male	Template:Navbox subgroup
SDS/DSD	Pseudohermaphroditism · True hermaphroditism · Mixed gonadal dysgenesis · Swyer syndrome · Persistent Mullerian duct syndrome
See also noncongenital, neoplasia

Polycystic kidney disease: Difference between revisions

Latest revision as of 15:30, 25 July 2018

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