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{{Hypogonadism}}
{{CMG}} {{AE}} {{AEL}}


{{Hypogonadism}}
{{CMG}}
==Overview==
==Overview==
==History==
The most common symptoms of hypogonadism in males include [[delayed puberty]] and loss of [[Sexual characteristics|sexual characters]] as voice deepening and [[hair]] growth. Common symptoms include also [[erectile dysfunction]], small [[testes]], [[loss of libido]] and [[sweating]]. Common symptoms in females include no [[breast enlargement]] and no [[pubic hair]]. Less common symptoms include a [[headache]], [[visual impairment]], [[galactorrhea]], and [[anorexia nervosa]].
==Symptoms==
 
Signs and symptoms depend on the cause.  
==History and symptoms==
History is important in the diagnosis of hypogonadism. The onset of the symptoms and previous [[Congenital anomalies|congenital gonadal anomalies]] should be known.
*For both males and females:
**History is important to know if there was any gonadal abnormality since birth or not. The onset of [[puberty]] should also be known.
**The family history of delay of growth and development increases the probability of [[Gonadotropins|gonadotropin hormones]] deficiency and hypogonadism. 
*For males:
**History of any causes of [[testicular]] failure as radiation to [[testes]], [[chemotherapy]] or [[drugs]] decreasing [[testosterone]] secretion.
*For females:
**[[Menstrual]] history is important and the date of [[menarche]].
**History of increased [[androgen]] secretion as [[acne]] and [[hirsutism]].  


*In female:
===Common symptoms in males===
:*Loss of [[menstruation]] and breast development during childhood
Symptoms of hypogonadism depend on the onset of the disease whether before puberty or after. The common symptoms of hypogonadism in are listed in the following table:<ref name="pmid27343020">{{cite journal| author=Khera M, Broderick GA, Carson CC, Dobs AS, Faraday MM, Goldstein I et al.| title=Adult-Onset Hypogonadism. | journal=Mayo Clin Proc | year= 2016 | volume= 91 | issue= 7 | pages= 908-26 | pmid=27343020 | doi=10.1016/j.mayocp.2016.04.022 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27343020  }} </ref><ref name="pmid24119423">{{cite journal| author=Basaria S| title=Male hypogonadism. | journal=Lancet | year= 2014 | volume= 383 | issue= 9924 | pages= 1250-63 | pmid=24119423 | doi=10.1016/S0140-6736(13)61126-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24119423  }} </ref><ref name="pmid20525905">{{cite journal| author=Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS et al.| title=Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. | journal=J Clin Endocrinol Metab | year= 2010 | volume= 95 | issue= 6 | pages= 2536-59 | pmid=20525905 | doi=10.1210/jc.2009-2354 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20525905  }} </ref>
:*Short height
:*Loss of menstruation, [[decreased libido]], [[hot flashes]], loss of body hair and [[infertility]] in adults.


*In male:
{| class="wikitable"
:*Lack of muscle and beard development during childhood
!Pre-pubertal
:*Growth problems
!Post-pubertal (Adult)
:*In adults: Sexual dysfunction, decreased beard and body hair, breast enlargement, muscle loss and [[infertility]].
|-
|Delayed puberty and loss of sexual characters:
* No beard
* Failure of voice deepening
* Small or absent [[testes]]
* [[Muscle wasting|No muscle mass gaining]]
* [[Micropenis]]
* [[Anosmia|Loss of smelling sense]] (In cases of [[Kallmann syndrome]])
|
* Decrease of [[libido]]
* Decreased [[Erection|erections]]
* [[Erectile dysfunction]]
* Decreased size of [[testes]]
* [[Sweating]]
* [[Breast enlargement]]
* Muscle loss and decreased [[bone density]]
* [[Infertility]]
* Loss of [[body hair]]
|}


*For hypogonadism caused by diseases from [[central nervous system]], patients may show symptoms of other hormonal deficiencies.
=== Common symptoms in female: ===
:*[[Headaches]]
* Delayed puberty and loss of the [[secondary sexual characteristics]]:
:*[[Visual loss]]
** No [[breast]] development
:*[[Galactorrhea]]
** No [[pubic hair]]  
:*[[Anorexia nervosa]]
:*[[Fatigue]] and [[weakness]]


Low Testosterone (Low T) symptoms include loss of energy, fatigue, loss of libido, muscle mass decline, decreased positive mood factors and an increased negative mood factors.
===Less common symptoms===
*[[Headaches]]
*[[Visual loss]]
*[[Galactorrhea]]
*[[Anorexia nervosa]]
*[[Fatigue]] and [[weakness]]
*[[Fatigue|Loss of energy]]
*[[Depression]]
*Sleeping disturbances
*Decreased work performance


==References==
==References==
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Latest revision as of 19:25, 3 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

The most common symptoms of hypogonadism in males include delayed puberty and loss of sexual characters as voice deepening and hair growth. Common symptoms include also erectile dysfunction, small testes, loss of libido and sweating. Common symptoms in females include no breast enlargement and no pubic hair. Less common symptoms include a headache, visual impairment, galactorrhea, and anorexia nervosa.

History and symptoms

History is important in the diagnosis of hypogonadism. The onset of the symptoms and previous congenital gonadal anomalies should be known.

  • For both males and females:
    • History is important to know if there was any gonadal abnormality since birth or not. The onset of puberty should also be known.
    • The family history of delay of growth and development increases the probability of gonadotropin hormones deficiency and hypogonadism.
  • For males:
  • For females:

Common symptoms in males

Symptoms of hypogonadism depend on the onset of the disease whether before puberty or after. The common symptoms of hypogonadism in are listed in the following table:[1][2][3]

Pre-pubertal Post-pubertal (Adult)
Delayed puberty and loss of sexual characters:

Common symptoms in female:

Less common symptoms

References

  1. Khera M, Broderick GA, Carson CC, Dobs AS, Faraday MM, Goldstein I; et al. (2016). "Adult-Onset Hypogonadism". Mayo Clin Proc. 91 (7): 908–26. doi:10.1016/j.mayocp.2016.04.022. PMID 27343020.
  2. Basaria S (2014). "Male hypogonadism". Lancet. 383 (9924): 1250–63. doi:10.1016/S0140-6736(13)61126-5. PMID 24119423.
  3. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS; et al. (2010). "Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab. 95 (6): 2536–59. doi:10.1210/jc.2009-2354. PMID 20525905.

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