DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1gene.[1][2][3]
Function
This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.[3]
References
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↑Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G (Jan 2000). "A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region". Genomics. 63 (1): 139–41. doi:10.1006/geno.1999.6040. PMID10662553.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J (Dec 2000). "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes". Mammalian Genome. 11 (12): 1127–31. doi:10.1007/s003350010213. PMID11130983.
Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D (Apr 2004). "Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein". Cancer Biology & Therapy. 3 (4): 377–81. doi:10.4161/cbt.3.4.724. PMID14726695.
Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D (Aug 2004). "Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene". Biochemical and Biophysical Research Communications. 321 (3): 611–6. doi:10.1016/j.bbrc.2004.07.007. PMID15358150.
Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D (Jan 2005). "ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase". Cancer Biology & Therapy. 4 (1): 60–4. doi:10.4161/cbt.4.1.1375. PMID15662122.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.
Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D (Aug 2007). "Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells". Carcinogenesis. 28 (8): 1622–8. doi:10.1093/carcin/bgm064. PMID17389617.
Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D (Dec 2007). "DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1". Cancer Investigation. 25 (8): 699–705. doi:10.1080/07357900701566304. PMID18058465.
