Wilms' tumor screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]
Overview
Screening can be very helpful to diagnose wilms tumor in high risk patients.Screening is done with serial abdominal ultrasonography.
Screening
- Screening can be very helpful to diagnose wilms tumor in high risk patients.[1]
- High risk patients include:
- Children with Beckwith-Wiedemann syndrome
- Children with WAGR syndrome
- Screening is done with serial abdominal ultrasonography.[2]
- Serial abdominal ultrasonography is done as follows:
- Children suffering from beckwith-wiedemann syndrome:
- Ultrasonography every three months until age seven years.
- Children suffering with WAGR and WT1-related syndromes:
- Ultrasonography every three months until age five years
- Siblings of an individual with familial wilms tumor:
- Ultrasonography every three months until age eight years.
- Offspring of survivors of bilateral wilms tumor:
- Ultrasonography every three months until age eight years.
- Children suffering from beckwith-wiedemann syndrome:
References
- ↑ Green DM, Breslow NE, Beckwith JB, Norkool P (1993). "Screening of children with hemihypertrophy, aniridia, and Beckwith-Wiedemann syndrome in patients with Wilms tumor: a report from the National Wilms Tumor Study". Med. Pediatr. Oncol. 21 (3): 188–92. PMID 8095320.
- ↑ Kalish JM, Doros L, Helman LJ, Hennekam RC, Kuiper RP, Maas SM, Maher ER, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz K, States LJ, Tomlinson GE, Zelley K, Druley TE (July 2017). "Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma". Clin. Cancer Res. 23 (13): e115–e122. doi:10.1158/1078-0432.CCR-17-0710. PMID 28674120. Vancouver style error: initials (help)