Whipple disease
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
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Overview
Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei.[1] First described by George Hoyt Whipple in 1907 [2][3] and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, lungs, brain, joints, and eyes. Weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system are common presenting symptoms.[4] When recognized and treated, Whipple's disease can usually be cured; untreated the disease may be fatal.
Symptoms
- arthritis
- malabsorption
- intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine)
- lymphadenopathy
- abdominal pain
- diarrhea
- fever
- neurological symptoms
- cognitive changes
- nystagmus
Diagnosis
Symptoms of Whipple's disease include joint problems, reduced vision, and intestinal inflammation (including diarrhea). Diagnosis is made by intestinal biopsy, which shows as PAS-positive macrophage inclusions.
At times, small bowel X-rays may show some thickened folds.
Treatment
Treatment is with penicillin, ampicillin, tetracycline or co-trimoxazole for 1 -2 years.[4] Any treatment lasting less than a year has an approximate relapse rate of 40%. In the January 4, 2007 issue of the New England Journal of Medicine, Fenollar et al suggest the use of doxycycline with hydroxychloroquine for 12 to 18 months. Sulfonamides (Sulfadiazine or Sulfamethoxazole) should be added for treatment of neurological symptoms.[5]
References
- ↑ Puéchal X (2002). "Whipple's disease". Joint Bone Spine 69 (2): 133-40. PMID 12027303.
- ↑ synd/3892 at Who Named It
- ↑ Whipple GH (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues". Bull Johns Hopkins Hosp 18: 382–93.
- ↑ 4.0 4.1 Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E (2004). "Whipple's disease". Clin Gastroenterol Hepatol 2 (10): 849-60. PMID 15476147.
- ↑ Fenollar F, Puéchal X, Raoult D (2007). "Whipple's disease". N Engl J Med 356 (1): 55-66. PMID 17202456.
External links
Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.
it:Morbo di Whipple de:Morbus Whipple
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
