Wernicke-Korsakoff syndrome

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Wernicke-Korsakoff syndrome Classification and external resources
Thiamine
ICD-10	E51.2, F10.6
ICD-9	294.0
OMIM	277730
MedlinePlus	000771
eMedicine	med/2405
MeSH	D020915

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Wernicke-Korsakoff syndrome is a manifestation of thiamine deficiency, or beri-beri. This is usually secondary to alcohol abuse.

Korsakoff's Psychosis and Wernicke's encephalopathy

The syndrome is a combined manifestation of two eponymous disorders, Korsakoff's Psychosis and Wernicke's encephalopathy, named for Drs. Sergei Korsakoff and Carl Wernicke.

Korsakoff's psychosis is characterized by

1. confusion.
2. anterograde and retrograde amnesia.
3. confabulation.

Wernicke's encephalopathy is characterized by

1. nystagmus
2. ophthalmoplegia
3. anisocoria
4. ataxia
5. sluggish pupillary reflexes
6. coma and death if untreated

Causes

Wernicke-Korsakoff syndrome results from thiamin deficiency. It is generally agreed that Wernicke's Encephalpathy results from severe acute deficiency of thiamine (Vitamin B₁), whilst Korsakoff's Psychosis results from chronic deficiency of thiamin. The metabolically active form of thiamin is thiamin diphosphate which plays a major role as a cofactor in glucose metabolism. The enzymes which are dependent on thiamin diphosphate are associated with the TCA Cycle and catalyse the oxidation of pyruvate,alphaketoglutarate and branched chain amino acids. Thus, anything that encourages glucose metabolism will exacerbate an existing clinical or sub-clinical thiamine deficiency.

As stated above, Wernicke-Korsakoff in the United States is usually found in malnourished chronic alcoholics, though it is also found in patients who undergo prolonged intravenous (IV) therapy, gastric stapling or intensive care unit (ICU) stays. In some regions, thiamin deficiency can be brought about by the chronic intake of polished rice, which is thiamine deficient, resulting in BeriBeri. In individuals with sub-clinical thiamine deficiency, a large dose of glucose (either as sweet food etc or glucose infusion), can precipitate the onset of overt encephalopathy. ^[1]

Wernicke-Korsakoff syndrome in alcoholics especially is associated with atrophy of specific regions of the brain, especially the mamillary bodies. Other regions include the anterior region of the thalamus (accounting for amnesic symptoms), the medial dorsal thalamus, the basal forebrain, and median and dorsal raphe nuclei.^[2]

One as-yet-unreplicated study has associated susceptiblity to this syndrome with a hereditary deficiency of transketolase, an enzyme involved in thiamine metabolism.^[3]

Diagnosis and findings

Diagnosis of Wernicke-Korsakoff syndrome is by clinical impression and can sometimes be confirmed with formal Neuropsychological assessment. Wernicke's encephalopathy typically presents with ataxia and nystagmus, and Korsakoff's psychosis with anterograde and retrograde amnesia and confabulation upon relevant lines of questioning.

Frequently, for unknown reasons, patients with Korsakoff's psychosis will exhibit marked degeneration of the mamillary bodies. The mechanism of this degeneration is unknown, but it supports current neurological theory that the mamillary bodies play a role in various "memory circuits" within the brain. An example of a memory circuit is the Papez circuit.

Treatment

Treatment consists of reversing the thiamine deficiency by giving supplemental thiamine, usually by starting with an initial intravenous or intramuscular dose followed by supplemental oral doses. It is important to start the thiamine treatment before giving any glucose as the encephalopathy will be worsened by the glucose. (Glucose administration promotes dehydrogenation of pyruvate, a biochemical reaction which consumes thiamine.) By the time amnesia and psychosis have occurred, complete recovery is unlikely.

References

de:Wernicke-Korsakow-Syndromis:Wernicke-Korsakoff heilkenni nl:Syndroom van Wernickesq:Sindroma Wernicke-Korsakoff