Transcription Factor II D
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| TATA box binding protein
| |
| Identifiers | |
| Symbol | TBP |
| Alt. Symbols | TFIID, GTF2D1, SCA17 |
| Entrez | 6908 |
| HUGO | 11588 |
| OMIM | 600075 |
| RefSeq | NM_003194 |
| UniProt | P20226 |
| Other data | |
| Locus | Chr. 6 q27 |
Transcription Factor II D (TFIID) is one of several basal transcription factors, all which are involved in the assembly of the basal apparatus of RNA polymerase II.[1] TFIID is itself composed of several subunits called TAFs (of which there are 14) and the TATA Binding Protein (TBP) of which only the TBP is necessary for a basal-level of transcription.
The TAFs of TFIID are necessary to increase the rate of transcription but can only do so when bound by activators. Some TAFs may provide sites that interact with different activators whilst some activators may interact with more than one TAF.
It is believed that activators assist in the binding of TFIID to the TATA box and/or binding of other transcriptional activators around the TFIID-TATA box complex, thereby increasing the rate of initiation
Transcription Factor II D is encoded by the TBP gene.[1]
See also
References
External links
Cell signaling | |
|---|---|
| Key concepts | Ligand - Signal transduction - Apoptosis - Second messenger system (Ca2+ signaling, Lipid signaling) |
| Processes | Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine) |
| Types of proteins | Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein |
| receptor ligands | hormones, neurotransmitters, cytokines, growth factors |
Transcription factors and intracellular receptors | |||||||||||||
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| (1) Basic domains |
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| (2) Zinc finger DNA-binding domains |
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| (3) Helix-turn-helix domains |
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| (4) β-Scaffold factors with minor groove contacts |
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| (0) Other transcription factors |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

