Ticarcillin
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| Ticarcillin
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| Systematic (IUPAC) name | |
| (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-yl- acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | J01 J01CR03 |
| PubChem | |
| Chemical data | |
| Formula | C15H16N2O6S2 |
| Mol. mass | 384.429 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 45% |
| Metabolism | ? |
| Half life | 1.1 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Intravenous |
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Ticarcillin is a carboxypenicillin. It is almost invariably sold and used in combination with clavulanate as Timentin®. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram negative bacteria, in particular, Pseudomonas aeruginosa.
Chemically, ticarcillin is C15H16N2O6S2 (CAS number 34787-01-4). It is provided as a white or pale yellow powder. It is highly soluble in water, but should only be dissolved immediately before use to prevent degradation.
Mechanism of action
Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.
Ticarcillin is similar to penicilin in that it contains a β-lactam ring. This can lead to resistance in bacteria containing β-lactamase, which cleaves the ring and inactivates it. It is often paired with a β-lactamase inhibitor such as clavulanic acid. Because of ticarcillins similarties to penicillin, including the β-lactam ring, it can cause similar allergic reactions in patients sensitive to penicillin.
Other uses
In molecular biology, ticarcillin is used to as an alternative to ampicillin to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.
Dosing and posology
Ticarcillin is not absorbed orally, and therefore must be given by intravenous or intramuscular injection. The usual adult dose of Timentin is 3.5g four times a day.
Trade names and preparations
- Ticarcillin: Ticar® (Formerly marketed by Beecham, then SmithKline Beecham until 1999, when it merged with Glaxo to form GlaxoSmithKline; no longer available in the UK. US distribution ceased in 2004. Ticar was replaced by Timentin.)
- Ticarcillin/clavulanate: Timentin® (UK and US, marketed by Beecham, then GlaxoSmithKline).
Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C) | |
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| Antibiotics | Amoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin |
| Beta-lactamase inhibitors | Sulbactam • Tazobactam • Clavulanic acid |
| Combinations | Ampicillin/sulbactam (Sultamicillin) • Co-amoxiclav |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
