Thorpe reaction

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The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.[1][2][3]

Thorpe-Ziegler reaction

The Thorpe-Ziegler reaction or Ziegler method is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.

External links

  • Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link


  1. ^  Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. J. Chem. Soc. 1904, 85, 1726.
  2. ^  Ziegler, K. et al. Ann. 1933, 504, 94.
  3. ^  Schaefer, J. P.; Bloomfield, J. J. Org. React. 1967, 15, 1. (Review)de:Thorpe-Ziegler-Reaktion