Thiamine pyrophosphate

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Thiamine pyrophosphate (TPP) or thiamine diphosphate (ThDP) is a thiamine derivative which is cleaved by thiamine pyrophosphatase. Thiamine phyrophosphate is the active form of thiamine (vitamin B1).[1]

ThDP is a prosthetic group in many enzymes, such as:


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