Tetrahydromethanopterin
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| Tetrahydromethanopterin | |
|---|---|
| Identifiers | |
| CAS number | |
| PubChem | |
| Properties | |
| Molecular formula | C30H45N6O16P |
| Molar mass | 776.682661 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Tetrahydromethanopterin, abbreviated H4MPT, is a coenzyme in methanogenesis. It is the carrier of the C1 group as it is reduced to the methyl level, before transferring to the coenzyme M.[1]
Tetrahydrosarcinapterin (H4SPT) is a modified form of H4MPT, wherein a glutamyl group linked to the 2-hydroxyglutaric acid terminus.
H4MPT is the main platform for C1 transformations
N-Formylmethanofuran donates the C1 group to the N5 site of the pterin to give the formylH4MPT.[1] The formyl group subsequently condenses intramolecularly to give methenylH4MPT+, which is then reduced to methyleneH4MPT.[1] MethyleneMPT is subsequently converted, using H2F420 as the electron source, to methylH4MPT, catalyzed by F420-dependent methylene-H4MPT reductase. MethylH4MPT is the methyl donor to coenzyme M, a conversion mediated by methyl-H4MPT:coenzyme M methyl-transferase.[1]
Comparison with tetrahydrofolate
H4MPT is related to the better known tetrahydrofolate (H4F). The differences are indicated in red and blue in the figure. The most important difference between H4MPT and H4F is that H4F has an electron-withdrawing carbonyl group on the phenyl ring. As a consequence, methenyl-H4MPT is more difficult to reduce than methenyl-H4F. Reduction is effected by a so-called Iron-sulfur cluster free hydrogenase.[1] The cumbersome name distinguishes this hydrogenase from the so-called Fe-only hydrogenases that do contain Fe-S cluster.
References
 | This biochemistry article is a stub. You can help WikiDoc by expanding it. |
| Major families of biochemicals | ||
| Peptides | Amino acids | Nucleic acids | Carbohydrates | Nucleotide sugars | Lipids | Terpenes | Carotenoids | Tetrapyrroles | Enzyme cofactors | Steroids | Flavonoids | Alkaloids | Polyketides | Glycosides | ||
| Analogues of nucleic acids: | Types of enzyme cofactors | Analogues of nucleic acids: |
| Coenzymes | NAD+ | NADP+ | Coenzyme A | Tetrahydrofolic acid | Menaquinone | Ascorbic acid | Coenzyme F420 | Adenosine triphosphate | S-Adenosyl methionine | 3'-Phosphoadenosine-5'-phosphosulfate | Coenzyme Q | Tetrahydrobiopterin | Cytidine triphosphate | Glutathione | Coenzyme M | Coenzyme B | Methanofuran | Tetrahydromethanopterin | |
|---|---|---|
| Prosthetic groups | ||
| Organic groups: | Flavin mononucleotide | Flavin adenine dinucleotide | Pyrroloquinoline quinone | Pyridoxal phosphate | Biotin | Methylcobalamin | Cobamamide | Thiamine pyrophosphate | Heme | Molybdopterin | Lipoic acid | |
| Metals: | Calcium | Copper | Iron | Magnesium | Manganese | Nickel | Zinc | |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
