Sticky platelet syndrome
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Sticky platelet syndrome is a term used by some[1][2][3][4] to describe a disorder of platelet function.[5]
Historical Perspective
It was first described by Mammen in 1983.[6]
Pathophysiology
It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.
Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein S deficiency and Factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.
Diagnosis
SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry platelet stickyness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[9] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.
Treatment
Those diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day.[10] Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.
Criticism
Critics of the diagnosis complain that case evidence is spotty and lacking controlled clinical studies.[11]
References
- ↑ Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5. doi:10.1055/s-2007-994939. PMID 10548069.
- ↑ Frenkel EP, Mammen EF (February 2003). "Sticky platelet syndrome and thrombocythemia". Hematol. Oncol. Clin. North Am. 17 (1): 63–83. doi:10.1016/S0889-8588(02)00096-5. PMID 12627663.
- ↑ Mears KA, Van Stavern GP (July 2008). "Bilateral Simultaneous Anterior Ischaemic Optic Neuropathy Associated with Sticky Platelet Syndrome". Br J Ophthalmol. 93 (7): 885–6, 913. doi:10.1136/bjo.2008.142919. PMID 18662911.
- ↑ Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL (1988). ""Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 115 (3): 361–5. PMID 2465231.
- ↑ Mühlfeld AS, Ketteler M, Schwamborn K; et al. (July 2007). "Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients". Am. J. Transplant. 7 (7): 1865–8. doi:10.1111/j.1600-6143.2007.01835.x. PMID 17532753.
- ↑ Bick, Rodger L (2006). Hematological complications in obstetrics, pregnancy, and gynecology. Cambridge, UK: Cambridge University Press. p. 147. ISBN 0-521-83953-X.
- ↑ McKay, Robert; David R. Gambling (2008). Obstetric anesthesia and uncommon disorders. Cambridge, UK: Cambridge University Press. p. 308. ISBN 0-521-87082-8.
- ↑ Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes". Cerebrovasc. Dis. 9 (2): 127–30. doi:10.1159/000015911. PMID 9973658.
- ↑ http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-47T2D4S-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fa06922a824e24db83382664b8659e30
- ↑ Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5. doi:10.1055/s-2007-994939. PMID 10548069.
- ↑ http://www.fvleiden.org/ask/78.html