Stauffer syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arise due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms. It is named for Dr. Maurice Stauffer, a gastroenterologist at the Mayo Clinic in Rochester, MN. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a paraneoplastic syndrome.

Stauffer syndrome causes abnormal liver function tests, especially those that reflect the presence of cholestasis, i.e. abnormal bile flow. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated.

Eponym

Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN, first characterized this syndrome in 1961, with the original name of "nephrogenic hepatomegaly."

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