Spin trapping

Jump to: navigation, search

Spin trapping is a technique employed in the study of free radicals that are either unstable or terminate rapidly at ambient temperatures.

Spin trapping involves the addition of a diamagnetic radical scavenger (the spin trap) to a reaction mixture containing a radical or radicals of interest. A reactive free radical adds to the scavenger, forming a long-lived paramagnetic adduct. This product can then be studied by EPR spectroscopy and the identity of the species adducted can be inferred from EPR spectral characteristics such as an observed g value or a hyperfine-coupling pattern.

One of the most commonly used spin traps is alpha-phenyl N-tertiary-butyl nitrone (PBN).

The use of radical-addition reactions to detect short-lived radicals was first proposed by E. G. Janzen in 1965.


Navigation WikiDoc | WikiPatient | Up To Date Pages | Recently Edited Pages | Recently Added Pictures

Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs

Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link Here
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies