Sjogren syndrome antigen B

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Sjogren syndrome antigen B (autoantigen La)
File:PBB Protein SSB image.jpg
PDB rendering based on 1owx.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols SSB ; LARP3; La
External IDs Template:OMIM5 Template:MGI HomoloGene: 2366
RNA expression pattern
File:PBB GE SSB 201138 s at tn.png
File:PBB GE SSB 201139 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Sjogren syndrome antigen B (autoantigen La), also known as SSB, is a human gene.[1]

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006).[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SSB Sjogren syndrome antigen B (autoantigen La)".

Further reading

  • Kohsaka H, Yamamoto K, Fujii H; et al. (1990). "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein". J. Clin. Invest. 85 (5): 1566–74. PMID 1692037.
  • Sturgess AD, Peterson MG, McNeilage LJ; et al. (1988). "Characteristics and epitope mapping of a cloned human autoantigen La". J. Immunol. 140 (9): 3212–8. PMID 2452201.
  • Rauh AJ, Hornig H, Lührmann R (1989). "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach". Eur. J. Immunol. 18 (12): 2049–57. PMID 2464497.
  • Chan EK, Sullivan KF, Tan EM (1989). "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding". Nucleic Acids Res. 17 (6): 2233–44. PMID 2468131.
  • Gottlieb E, Steitz JA (1989). "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III". EMBO J. 8 (3): 851–61. PMID 2470590.
  • Chambers JC, Kenan D, Martin BJ, Keene JD (1989). "Genomic structure and amino acid sequence domains of the human La autoantigen". J. Biol. Chem. 263 (34): 18043–51. PMID 3192525.
  • Chambers JC, Keene JD (1985). "Isolation and analysis of cDNA clones expressing human lupus La antigen". Proc. Natl. Acad. Sci. U.S.A. 82 (7): 2115–9. PMID 3856888.
  • Svitkin YV, Pause A, Sonenberg N (1994). "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA". J. Virol. 68 (11): 7001–7. PMID 7933082.
  • Tröster H, Metzger TE, Semsei I; et al. (1994). "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome". J. Exp. Med. 180 (6): 2059–67. PMID 7964483.
  • Fan H, Sakulich AL, Goodier JL; et al. (1997). "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes". Cell. 88 (5): 707–15. PMID 9054510.
  • McLaren RS, Caruccio N, Ross J (1997). "Human La protein: a stabilizer of histone mRNA". Mol. Cell. Biol. 17 (6): 3028–36. PMID 9154801.
  • Grölz D, Bachmann M (1997). "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs". Biochem. J. 323 ( Pt 1): 151–8. PMID 9173875.
  • Helsloot J, Sturgess A (1998). "T cell reactivity to Sjögren's syndrome related antigen La(SSB)". J. Rheumatol. 24 (12): 2340–7. PMID 9415639.
  • Broekhuis CH, Neubauer G, van der Heijden A; et al. (2000). "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution". Biochemistry. 39 (11): 3023–33. PMID 10715123.
  • Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
  • Intine RV, Sakulich AL, Koduru SB; et al. (2000). "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366". Mol. Cell. 6 (2): 339–48. PMID 10983981.
  • Nashimoto M, Nashimoto C, Tamura M; et al. (2001). "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs". J. Mol. Biol. 312 (5): 975–84. doi:10.1006/jmbi.2001.5026. PMID 11580243.
  • De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM (2002). "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA". Virology. 295 (2): 337–47. doi:10.1006/viro.2002.1407. PMID 12033793.
  • Intine RV, Dundr M, Misteli T, Maraia RJ (2002). "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs". Mol. Cell. 9 (5): 1113–23. PMID 12049746.
  • Fouraux MA, Bouvet P, Verkaart S; et al. (2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". J. Mol. Biol. 320 (3): 475–88. PMID 12096904.

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