Sickle cell trait

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Sickle cell trait Classification and external resources
ICD-10	D57.3
ICD-9	282.5
MeSH	D012805

WikiDoc Resources for Sickle cell trait
Articles
Most recent articles on Sickle cell trait Most cited articles on Sickle cell trait Review articles on Sickle cell trait Articles on Sickle cell trait in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Sickle cell trait Images of Sickle cell trait Photos of Sickle cell trait Podcasts & MP3s on Sickle cell trait Videos on Sickle cell trait
Evidence Based Medicine
Cochrane Collaboration on Sickle cell trait Bandolier on Sickle cell trait TRIP on Sickle cell trait
Clinical Trials
Ongoing Trials on Sickle cell trait at Clinical Trials.gov Trial results on Sickle cell trait Clinical Trials on Sickle cell trait at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Sickle cell trait NICE Guidance on Sickle cell trait NHS PRODIGY Guidance FDA on Sickle cell trait CDC on Sickle cell trait
Books
Books on Sickle cell trait
News
Sickle cell trait in the news Be alerted to news on Sickle cell trait News trends on Sickle cell trait
Commentary
Blogs on Sickle cell trait
Definitions
Definitions of Sickle cell trait
Patient Resources / Community
Patient resources on Sickle cell trait Discussion groups on Sickle cell trait Patient Handouts on Sickle cell trait Directions to Hospitals Treating Sickle cell trait Risk calculators and risk factors for Sickle cell trait
Healthcare Provider Resources
Symptoms of Sickle cell trait Causes & Risk Factors for Sickle cell trait Diagnostic studies for Sickle cell trait Treatment of Sickle cell trait
Continuing Medical Education (CME)
CME Programs on Sickle cell trait
International
Sickle cell trait en Espanol Sickle cell trait en Francais
Businness
Sickle cell trait in the Marketplace Patents on Sickle cell trait
Experimental / Informatics
List of terms related to Sickle cell trait

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Sickle cell trait describes the way a person can inherit some of the genes of sickle cell disease, but not develop symptoms. Sickle cell disease is a blood disorder in which the body produces an abnormal type of the oxygen-carrying substance hemoglobin in the red blood cells.

Normal hemoglobin is called hemoglobin A, but people with sickle cell disease have only hemoglobin S, which turns normal, round red blood cells into abnormally curved (sickle) shapes.

Normally, a person inherits two genes (one from each parent) that produce beta-globin, a protein needed to produce normal hemoglobin (hemoglobin A). A person with sickle cell trait inherits one normal beta-globin gene (hemoglobin A) and one defective gene (hemoglobin S).

People with sickle cell trait rarely have symptoms due to the condition because they also have some normal hemoglobin. However, they can pass the sickle cell trait to their children, and in rare cases, exercise-induced dehydration or exhaustion can cause healthy red blood cells to turn sickle-shaped, which can cause death.

A person in whom both beta-globin genes are abnormal (they produce hemoglobin S) has sickle cell disease, which can cause serious problems. Both parents must have either the sickle cell trait or the disease itself for a child to have sickle cell disease.

People who have the sickle cell trait have reduced susceptibility to malaria, due to natural selection for the heterozygote advantage. However, people with the sickle cell trait can still contract severe cases of malaria.

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome, Eosinopenia, Basopenia)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for Sickle cell trait
Articles on Sickle cell trait	Most recent articles on Sickle cell trait • Most cited articles on Sickle cell trait • Review articles on Sickle cell trait • Articles on Sickle cell trait in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Sickle cell trait	Powerpoint slides on Sickle cell trait • Images of Sickle cell trait • Photos of Sickle cell trait • Podcasts & MP3s on Sickle cell trait • Videos on Sickle cell trait
Evidence Based Medicine Regarding Sickle cell trait	Cochrane Collaboration on Sickle cell trait • Bandolier on Sickle cell trait • TRIP on Sickle cell trait
Cost Effectiveness of Sickle cell trait	Cost Effectiveness of Sickle cell trait
Clinical Trials Involving Sickle cell trait	Ongoing Trials on Sickle cell trait at Clinical Trials.gov • Trial results on Sickle cell trait • Clinical Trials on Sickle cell trait at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Sickle cell trait	US National Guidelines Clearinghouse on Sickle cell trait • NICE Guidance on Sickle cell trait • NHS PRODIGY Guidance • FDA on Sickle cell trait • CDC on Sickle cell trait
Textbook Information on Sickle cell trait	Books and Textbook Information on Sickle cell trait
Pharmacology Resources on Sickle cell trait	Dosing of Sickle cell trait • Drug interactions with Sickle cell trait • Side effects of Sickle cell trait • Allergic reactions to Sickle cell trait • Overdose information on Sickle cell trait • Carcinogenicity information on Sickle cell trait • Sickle cell trait in pregnancy • Pharmacokinetics of Sickle cell trait •
Genetics, Pharmacogenomics, and Proteinomics of Sickle cell trait	Genetics of Sickle cell trait • Pharmacogenomics of Sickle cell trait • Proteomics of Sickle cell trait
Newstories on Sickle cell trait	Sickle cell trait in the news • Be alerted to news on Sickle cell trait • News trends on Sickle cell trait
Commentary on Sickle cell trait	Blogs on Sickle cell trait
Patient Resources on Sickle cell trait	Patient resources on Sickle cell trait • Discussion groups on Sickle cell trait • Patient Handouts on Sickle cell trait • Directions to Hospitals Treating Sickle cell trait • Risk calculators and risk factors for Sickle cell trait
Healthcare Provider Resources on Sickle cell trait	Symptoms of Sickle cell trait • Causes & Risk Factors for Sickle cell trait • Diagnostic studies for Sickle cell trait • Treatment of Sickle cell trait
Continuing Medical Education (CME) Programs on Sickle cell trait	CME Programs on Sickle cell trait
International Resources on Sickle cell trait	Sickle cell trait en Espanol • Sickle cell trait en Francais
Business Resources on Sickle cell trait	Sickle cell trait in the Marketplace • Patents on Sickle cell trait
Informatics Resources on Sickle cell trait	List of terms related to Sickle cell trait

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .