Serotonin receptor agonist

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A serotonin receptor agonist is a compound that activates serotonin receptors, mimicking the effect of the neurotransmitter serotonin. There are various serotonin receptors

5-HT_1A receptor

Buspirone, a 5-HT_1A receptor agonist that is an anxiolytic medication.

5-HT_1D receptor

Triptans are 5-HT_1D receptor agonists that are used to abort migraine attacks.

5-HT_2A receptor

Hallucinogens like LSD, mescaline and psilocybin act as 5-HT_2A agonists, and action at this receptor is thought to be primarily responsible for their hallucinogenic effects (although the 5-HT_1A and 5-HT_2C receptors are also involved to a lesser extent)

5-HT₄ receptor

Cisapride is a 5-HT₄ receptor agonist that has been used to treat disorders of gastrointestinal motility.

See also

• Agonist

External links

• IUPHAR GPCR Database - 5-HT receptor family
• MeSH list of agents 82017366
• MeSH Serotonin+agonists

v • d • e Drugs for functional gastrointestinal disorders (A03)
Drugs for functional bowel disorders	antimuscarinics: Mebeverine - Dicycloverine - Propantheline papaverine and derivatives: Papaverine - Drotaverine - Moxaverine acting on serotonin receptors: 5-HT3 antagonists (Alosetron, Cilansetron) - 5HT4 agonists (Mosapride, Tegaserod) other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl
Belladonna and derivatives (antimuscarinics)	Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine
Propulsives	primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride

v • d • e Antimigraine preparations (N02C)
Ergot alkaloids	Dihydroergotamine • Ergotamine • Methysergide • Lisuride
Corticosteroid derivatives	Flumedroxone
Selective serotonin (5-HT1) agonists	Triptans (Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan)
Other antimigraine preparations	Pizotifen • Clonidine • Topiramate • Iprazochrome • Dimetotiazine • Oxetorone

v • d • e Psycholeptics: anxiolytics (tranquilisers) (N05B)
Benzodiazepine	Adinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam
Nonbenzodiazepine	Adipiplon - Alpidem - CGS-9896 - CGS-20625 - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684
Diphenylmethane	Hydroxyzine - Captodiame
Carbamates	Emylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate
β-Carbolines	Abecarnil - Gedocarnil - SL-651,498
Dibenzo-bicyclo-octadiene	Benzoctamine
Azaspirodecanedione (serotonin agonist)	Buspirone - Flesinoxan - Gepirone - Tandospirone
Other	Eglumegad - Etazolate - Mephenoxalone - Saredutant

v • d • e Receptor agonists, antagonists, and reuptake inhibitors
BA/M: 5-HT (serotonin) receptor	Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI)
BA/M: Dopamine receptor	Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor
BA/M: Adrenergic receptor	Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor
BA/M: Histamine receptor	Histamine agonist • Histamine antagonist (H1, H2)
Acetylcholine receptor	Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor
AA: GABA receptor	GABA agonist • GABA antagonist
AA: Glutamate receptor	NMDA receptor (NMDA receptor antagonist)