Semaphorin 3E

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene.

Function

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

Further reading

• Lalani SR, Safiullah AM, Molinari LM, Fernbach SD, Martin DM, Belmont JW (July 2004). "SEMA3E mutation in a patient with CHARGE syndrome". J. Med. Genet. 41 (7): e94. PMC 1735828. PMID 15235037.
• Kigel B, Varshavsky A, Kessler O, Neufeld G (September 2008). "Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells". PLoS ONE. 3 (9): e3287. doi:10.1371/journal.pone.0003287. PMC 2538586. PMID 18818766.
• Roodink I, Kats G, van Kempen L, Grunberg M, Maass C, Verrijp K, Raats J, Leenders W (December 2008). "Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression". Am. J. Pathol. 173 (6): 1873–81. doi:10.2353/ajpath.2008.080136. PMC 2626397. PMID 18974298.
• Sokolowski M, Wasserman J, Wasserman D (January 2010). "Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters". Mol. Psychiatry. 15 (1): 10–1. doi:10.1038/mp.2009.70. PMID 20029409.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Mazzone M, Comoglio PM, Tamagnone L (August 2010). "Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice". J. Clin. Invest. 120 (8): 2684–98. doi:10.1172/JCI42118. hdl:2318/130565. PMC 2912191. PMID 20664171.
• Blanc V, Nariculam J, Munson P, Freeman A, Klocker H, Masters J, Williamson M (May 2011). "A role for class 3 semaphorins in prostate cancer". Prostate. 71 (6): 649–58. doi:10.1002/pros.21281. PMID 20949546.
• Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A (May 2011). "Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice". J. Clin. Invest. 121 (5): 1974–85. doi:10.1172/JCI44900. PMC 3083763. PMID 21505259.
• Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle". J. Biol. Chem. 286 (26): 23521–32. doi:10.1074/jbc.M111.220178. PMC 3123115. PMID 21555518.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.