SEC23-interacting protein is a protein that in humans is encoded by the SEC23IPgene.[1][2]
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.[2]
References
↑Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID10400679.
Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID16510448.
Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi:10.1074/jbc.M409673200. PMID15623529.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
