Ribavirin microbiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Microbiology
Antiviral Activity in Cell Culture
The antiviral activity of ribavirin in the HCV-replicon is not well understood and has not been defined because of the cellular toxicity of ribavirin. Direct antiviral activity has been observed in tissue culture of other RNA viruses. The anti-HCV activity of interferon was demonstrated in cell containing self-replicating HCV-RNS (HCV replicon cells) or HCV infection.
Resistance
HCV genotypes show wide variability in their response to pegylated recombinant human interferon/ribavirin therapy. Genetic changes associated with the variable response have not been identified.
Cross-resistance
There is no reported cross-resistance between pegylated/non-pegylated interferons and ribavirin.[1]
References
- ↑ "REBETOL (RIBAVIRIN) CAPSULE REBETOL (RIBAVIRIN) LIQUID [MERCK SHARP & DOHME CORP.]". Retrieved 6 January 2014.
Adapted from the FDA Package Insert.