Pseudomyxoma peritonei causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Parminder Dhingra, M.D. [3]
Overview
Pseudomyxoma peritonei is a rare disease caused by a pre-existing intraperitoneal mucinous neoplasm, accumulation of fluids in abdominal cavity causes mass impact on vital organs such as the spleen, kidney, and pancreas. The pathology and causes of pseudomyxoma peritonei are poorly understood. It is shown in some studies that the K-Ras and p53 genes may be involved in the oncogenesis.
Causes
- Studies have shown and supported that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon.[1]
- The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.[2]
- The K-Ras and p53 genes may be involved in the oncogenesis. It was shown in studies that overexpression of p53 was in correlation with female sex, highe-grade disease, and worse survival.[3]
References
- ↑ Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B (October 2012). "Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases". J. Clin. Pathol. 65 (10): 919–23. doi:10.1136/jclinpath-2012-200843. PMID 22718846.
- ↑ O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH (August 2002). "Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells". Am. J. Pathol. 161 (2): 551–64. doi:10.1016/S0002-9440(10)64211-3. PMID 12163380.
- ↑ Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B (March 2013). "Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis". J. Surg. Res. 180 (1): 97–103. doi:10.1016/j.jss.2012.10.053. PMID 23199549.