Propanidid

250px
Propanidid
Systematic (IUPAC) name
propyl 2-[4-(diethylcarbamoylmethoxy)-3-methoxy- phenyl]acetate
Identifiers
CAS number	1421-14-3
ATC code	N01AX04
PubChem	15004
Chemical data
Formula	C18H27NO5
Mol. mass	337.411 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer but anaphylactic reactions caused it to be withdrawn shortly afterwards.

Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intraveneosly and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.

It has been argued that the toxic effects or reactions to Propanidid (and Althesin) were due to the drugs themselves . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.

External links

• Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G (1995). "Anesthesia with propanidid in a liposomal preparation. An experimental study in swine". Anaesthesist 44 (8): 573-80. PMID 7573906.
• Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A (1992). "Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats". Anaesthesist 41 (8): 448-56. PMID 1524155.
• Zawisza P, Przyborowski L (1992). "Propanidid and etomidate identification from the blood by thin-layer chromatography". Acta Pol Pharm 49 (5-6): 15-7. PMID 16092193.

• Theis JG, et al. "Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL". Journal of Clinical Oncology] 13: 2508-2516.

• Ebo DG, et al. "IgE-mediated anaphylaxis after first intravenous infusion of cyclosporine". Annals of Allergy, Asthma and Immunology 87 (3): 243-245.