Primary cutaneous follicle centre lymphoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overvew

The predominant therapy for primary cutaneous follicle centre lymphoma is radiotherapy. Adjunctive chemotherapy may be required.[1][2]

Medical Therapy

  • Surgical removal and/or radiotherapy is given for localized disease.[1][2]
  • Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.[1]:314[3][4][2]
  • For the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used.[1][3][4][2]Intralesional interferon alpha (IFN-α)[5]and intralesional rituximab have been used.[1][5]
  • Approximately one-third of primary cutaneous follicle centre lymphoma relapse, usually in the skin; treatment is similar to initial management[2] and overall survival remains excellent.[6]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
Post-radiotherapy appearance.[7]
Post-radiotherapy appearance.[7]

References

  1. 1.0 1.1 1.2 1.3 1.4 Jaffe, ES (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406. Unknown parameter |coauthors= ignored (help)
  2. 2.0 2.1 2.2 2.3 2.4 Wilcox RA (2015). "Cutaneous B-cell lymphomas: 2015 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 90 (1): 73–6. doi:10.1002/ajh.23863. PMID 25535037.
  3. 3.0 3.1 Armitage, JO; Mauch PM; Harris NL; et al. (2010). "Chapter 24". Non-Hodgkin Lymphomas (2nd ed.). Lippincott Williams & Wilkins. ISBN 9780781791168.
  4. 4.0 4.1 Sokol L, Naghashpour M, Glass LF (2012). "Primary cutaneous B-cell lymphomas: recent advances in diagnosis and management". Cancer Control. 19 (3): 236–44. PMID 22710899.
  5. 5.0 5.1 Senff NJ, Noordijk EM, Kim YH, et al. (2008). "European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas". Blood. 112 (5): 1600–9. doi:10.1182/blood-2008-04-152850. PMID 18567836.
  6. Suárez AL, Querfeld C, Horwitz S, et al. (2013). "Primary cutaneous B-cell lymphomas: part II. Therapy and future directions". J. Am. Acad. Dermatol. 69 (3): 343.e1–11, quiz 355–6. doi:10.1016/j.jaad.2013.06.011. PMID 23957985.
  7. 7.0 7.1 7.2 7.3 Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016

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