Prickle planar cell polarity protein 2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Prickle planar cell polarity protein 2 is a protein that in humans is encoded by the PRICKLE2 gene.

Function

This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011].

Further reading

• Katoh M, Katoh M (February 2003). "Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle". Int. J. Mol. Med. 11 (2): 249–56. PMID 12525887.
• Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S (January 2012). "Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation". Mol. Cell. Biol. 32 (1): 173–85. doi:10.1128/MCB.06320-11. PMC 3255712. PMID 22037766.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.