Picrotoxin
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| Image:Picrotoxin 3D sticks.png | |
| Picrotoxin
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C30H34O13 |
| Mol. mass | 602.583 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Routes | ? |
Picrotoxin, also known as cocculin, is a poisonous crystalline plant alkaloid, first isolated by Boullay in 1812.
Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.
Chemical structure
Picrotoxin (C30H34O13) consists of two substances, picrotoxinin (C15H1606) and picrotin (C15H1807).
References
- L. Dupont, O. Dideberg, J. Lamotte-Brasseur et L. Angenot (1976). "Structure cristalline et moléculaire de la picrotoxine, C15H16O6.C15H18O7". Acta Cryst. B32: 2987-2993. (in French)
External links
- Ehrenberger K, Benkoe E, Felix D (1982). "Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man". Acta Otolaryngol. 93 (3-4): 269-73. PMID 7064710.
- Basic Neurochemistry: GABA Receptor Physiology and Pharmacology
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
