| Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Phosphatidylserine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function.  In apoptosis, phosphatidylserine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. PS has been shown to slow cognitive decline in animal models. . PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly. Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.
- DrugBank info page
- Phosphatidylserine and Cognitive Dysfunction and Dementia
- MeSH Phosphatidylserines
- Micheau J, Riedel G. (1999). "Protein kinases: which one is the memory molecule?". Cell Mol Life Sci. 55 (4): 534–48. PubMed.
- McDaniel MA, Maier SF, Einstein GO. (2003). ""Brain-specific" nutrients: a memory cure?". Nutrition. 19 (11-12): 957–75. PubMed.
- Kingsley M. (2006). "Effects of phosphatidylserine supplementation on exercising humans". Sports Medicine. 36 (8): 657–69. PubMed.