Phosphatidylserine
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| Phosphatidylserine | |
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| Identifiers | |
| CAS number | |
| PubChem | |
| Properties | |
| Molecular formula | C13H24NO10P |
| Molar mass | 385.304 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Phosphatidylserine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. [1] In apoptosis, phosphatidylserine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. PS has been shown to slow cognitive decline in animal models. [2]. PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly. Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.
The dietary supplement was originally processed from bovine sources however Prion disease scares in the 1990s outlawed this process, and a soy-based alternative was adopted. [3].
External links
- DrugBank info page
- Phosphatidylserine and Cognitive Dysfunction and Dementia
- MeSH Phosphatidylserines
References
- ↑ Micheau J, Riedel G. (Apr 1999). "Protein kinases: which one is the memory molecule?". Cell Mol Life Sci. 55 (4): 534-48. PubMed. Retrieved on 2007-09-25.
- ↑ McDaniel MA, Maier SF, Einstein GO. (Nov-Dec 2003). ""Brain-specific" nutrients: a memory cure?". Nutrition 19 (11-12): 957-75. PubMed.
- ↑ Kingsley M. (2006). "Effects of phosphatidylserine supplementation on exercising humans". Sports Medicine 36 (8): 657-69. PubMed.
Lipids: phospholipids | |
|---|---|
| Glycerol backbone (Glycerophospholipids/ Phosphoglycerides) | Phosphatidyl-: -ethanolamine/cephalin - -choline/lechithin (dipalmitoyl-) - -serine - -glycerol - -inositol (glyco-)
phosphatidylinositol phosphates: PIP1 - PIP2 (3,4, 3,5, 4,5) - PIP3 Ether lipids: Plasmalogen (Platelet-activating factor) |
| Sphingosine backbone | Sphingomyelin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
