Pharmacogenomics
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Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimised for each individual's unique genetic makeup.[1]
Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs.
See also
External links
- Genomics @ FDA FDA's resource on genomics
- [2]Pharmacogenetics and Genomics magazine (previously Pharmacogenetics)
- [3]The Pharmacogenomics Journal, ISSN: 1470-269X
- [4]Pharmacogenomics Journal, (ISSN 1462-2416) Impact factor: 3.623
- Nature pharmacogenomics gateway
- PharmGKB The Pharmacogenetics and Pharmacogenomics Knowledge Base, an online free tool for Pharmacogenomics research
- NCBI Primer on Pharmacogenomics, a quick introduction to the promise of customised drugs.
- Pharmacogenomics: Drugs Designed for You, an accessible and comprehensive look at pharmacogenomics research, from the University of Utah's Genetic Science Learning Center
- A Drug to Call One's Own : Will medicine finally get personal? - Scientific American Magazine (August 2005)
References
- ↑ Guidance for Industry Pharmacogenomic Data Submissions (PDF). U.S. Food and Drug Administration (March 2005). Retrieved on 2008-08-27.
| Genomics topics |
| Genome project | Paleopolyploidy | Glycomics | Human Genome Project | Proteomics |
| Chemogenomics | Structural genomics | Pharmacogenetics | Pharmacogenomics | Toxicogenomics | Computational genomics |
| Bioinformatics | Cheminformatics | Systems biology |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

