Peritonitis secondary prevention

Peritonitis Main Page
Patient Information
Overview
Causes
Classification Spontaneous Bacterial Peritonitis Secondary Peritonitis
Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivani Chaparala M.B.B.S [2]

Secondary Prevention

• PBP has a high rate of recurrence.
• Up to 70% of patients experience a recurrence within 1 year.
• Antibiotic prophylaxis is recommended for patients with a history of PBP to reduce this rate to <20% and improve short-term survival rates.
• Prophylactic regimens for adults with normal renal function include

fluoroquinolones (ciprofloxacin, 750 mg weekly; norfloxacin, 400 mg/d) or 
trimethoprim-sulfamethoxazole (one double-strength tablet daily). 

• However, long-term administration of broad-spectrum antibiotics has been shown to increase the risk of severe infections by multi-drug resistant organisms.