p16INK4a
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It has been suggested that this article or section be merged into P16 (gene). (Discuss) |
| cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
| |
| Identifiers | |
| Symbol | CDKN2A |
| Alt. Symbols | CDKN2, MLM |
| Entrez | 1029 |
| HUGO | 1787 |
| OMIM | 600160 |
| RefSeq | NM_000077 |
| UniProt | P42771 |
| Other data | |
| Locus | Chr. 9 p21 |
p16INK4a is a major product of the CDKN2A locus. Its alternate reading frame product is p14ARF. p16INK4a regulates the cell cycle by binding and deactivating various cyclin-CDKcomplexes.
A study published in 2007 in the New England Journal of medicine established that there is a strong association between polymorphisms on chromosome 9p21.3 (SNP, rs1333049) and coronary artery disease. This region codes for the INK4 proteins p16INK4a and p15INK4b. The corresponding genes are CDKN2A and CDKN2B. The proteins may inhibit cell growth induced by Transforming Growth Factor-beta.
External links
- "Scientists study mammalian aging" at United Press International
- Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE (2006). "p16INK4a induces an age-dependent decline in islet regenerative potential". Nature 443 (7110): 453-7. PMID 16957737.
- NEJM 2007 Genomewide Association Analysis of Coronary Artery Disease
Cell cycle proteins | |
|---|---|
| Cyclin | A - B - D - E |
| Cyclin-dependent kinase | 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase |
| Cyclin-dependent kinase inhibitor protein | p14arf/p16INK4a - p21 - p27 - p57 |
| Other | Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
