Oxygen Enhancement Ratio
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Overview
The Oxygen Enhancement Ratio (OER) in radiobiology refers to the enhancement of therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. The effect is most notable in ionizing radiation dose.
Uses in medicine
The effect is used in medical physics to increase the effect of radiation therapy in oncology treatments. Additional oxygen abundance creates additional free radicals and increases the damage to the target tissue.
In solid tumors the inner parts become less oxygenated than normal tissue and up to three times higher dose is needed to achieve the same tumor control probability as in tissue with normal oxygenation.
See also
References
Eric J. Hall and Amato J. Giaccia: Radiobiology for the radiologist, Lippincott Williams & Wilkins, 6th Ed., 2006
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
