Ototoxicity
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| Ototoxic hearing loss Classification and external resources | |
| ICD-10 | H91.0 |
|---|---|
| DiseasesDB | 2874 |
| eMedicine | ent/699 |
Ototoxicity is damage of the ear (oto), specifically the cochlea or auditory nerve and sometimes the vestibulum, by a toxin (often medication).
Causes
A number of drugs have been associated with damage to the cochlea. The best known are aminoglycoside antibiotics, aspirin, nicotine and some diuretics such as furosemide.
Erythromycin and some other macrolide antibiotics can induce temporary deafness, which resolves upon withdrawal of the drug.
Other chemicals such as toluene, mercury and carbon monoxide are also known Ototoxic chemicals.
There appears to be a hereditary predisposition to ototoxic reactions.
Symptoms
Symptoms include partial or profound hearing loss, vertigo, and tinnitus.
Treatment
No specific treatment is available, but immediate withdrawal of the drug is warranted.
See also
External links
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
