Ornithine
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| Ornithine | |
|---|---|
| |
| IUPAC name | 2,5-diaminopentanoic acid |
| Identifiers | |
| CAS number | |
| PubChem | |
| MeSH | |
| SMILES | C(CC(C(=O)O)N)CN |
| Properties | |
| Molecular formula | C5H12N2O2 |
| Molar mass | 132.161 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Ornithine is an amino acid, whose structure is:
Role in urea cycle
Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen.
Ornithine is not an amino acid coded for by DNA, and in that sense, is not involved in protein synthesis. However, in mammalian non-hepatic tissues, the main use of the urea cycle is in arginine biosynthesis, so as an intermediate in metabolic processes, ornithine is quite important.
Lactamization
It is believed to not be a part of genetic code because polypeptides containing unprotected ornithines undergo spontaneous lactamization. This proved to be a problem when ornithine was artificially incorporated in 21st amino acid systems.
Other reactions
Ornithine, via the action of ornithine decarboxylase (E.C. 4.1.1.17), is the starting point for the synthesis of polyamines such as putrescine.
In bacteria, such as E. coli, ornithine can be synthesized from L-glutamate.[1]
References
de:Ornithinfr:Ornithine it:Ornitina nl:Ornithine ja:オルニチンth:ออร์นิทีน
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
