Nuclear receptor coactivator 1

Nuclear receptor coactivator 1
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PDB rendering based on 1oj5.
Identifiers
Symbol(s)	NCOA1; SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160
External IDs	OMIM: 602691 MGI: 1276523 Homologene: 7859
Gene ontology Molecular Function: • DNA binding • chromatin binding • transcription coactivator activity • histone acetyltransferase activity • signal transducer activity • receptor activity • protein binding • acyltransferase activity • transferase activity • transcription regulator activity • androgen receptor binding Cellular Component: • nucleus Biological Process: • regulation of transcription, DNA-dependent • signal transduction • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent
RNA expression pattern
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Orthologs
	Human	Mouse
Entrez	8648	17977
Ensembl	ENSG00000084676	ENSMUSG00000020647
Uniprot	Q15788	Q3U3A3
Refseq	NM_003743 (mRNA) NP_003734 (protein)	XM_001000135 (mRNA) XP_001000135 (protein)
Location	Chr 2: 24.66 - 24.85 Mb	Chr 12: 4.26 - 4.49 Mb
Pubmed search	[1]	[2]

The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

External links

• MeSH nuclear+receptor+coactivator+1

Further reading

• Qi C, Zhu Y, Reddy JK (2001). "Peroxisome proliferator-activated receptors, coactivators, and downstream targets.". Cell Biochem. Biophys. 32 Spring: 187-204. PMID 11330046.

it:Coattivatore del recettore nucleare 1