Norethisterone
| |
| Norethisterone
| |
| Systematic (IUPAC) name | |
| (17β)-17-ethynyl-17-hydroxyestr-4-en-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | G03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H26O2 |
| Mol. mass | 298.419 g/mol |
| Synonyms | (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-13-methyl-1, 2,6,7,8,9,10,11,12,14,15, 16-dodecahydrocyclopenta[a]phenanthren-3-one |
| Pharmacokinetic data | |
| Bioavailability | 64% |
| Protein binding | >95% |
| Metabolism | ? |
| Half life | 7 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
|
WikiDoc Resources for Norethisterone | |
|
Articles | |
|---|---|
|
Most recent articles on Norethisterone Most cited articles on Norethisterone | |
|
Media | |
|
Powerpoint slides on Norethisterone | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Norethisterone at Clinical Trials.gov Trial results on Norethisterone Clinical Trials on Norethisterone at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Norethisterone NICE Guidance on Norethisterone
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Norethisterone Discussion groups on Norethisterone Patient Handouts on Norethisterone Directions to Hospitals Treating Norethisterone Risk calculators and risk factors for Norethisterone
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Norethisterone | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Business | |
|
Experimental / Informatics | |
Overview
Norethisterone (or norethindrone) (or 19-nor-17α-ethynyltestosterone) is a molecule used in some combined oral contraceptive pills and in some progestogen only pills. It is a progestogen and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period. Norethindrone was the first orally highly active progestin to be synthesized. It was synthesized for the first time by chemists Luis E. Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951.[1] It was the progestin used in one of the first two oral contraceptives. It is often used as the related ester, norethisterone acetate.
References
- ↑ Djerassi C, Miramontes L, Rosenkranz G, Sondheimer F (1954). "Steroids. LIV. Synthesis of 19-Nor-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone" (abstract page). J Am Chem Soc 76 (16): 4089–4091. doi:10.1021/ja01645a009.
Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs
Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link HereThere is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
