Motor nerve cell from ventral horn of medulla spinalis of rabbit. The angular and spindle-shaped Nissl bodies are well shown.
A Nissl body (or Nissl granule or tigroid body) is a large granular body found in neurons. It was named after Franz Nissl, German neurologist (1860-1919).
Nissl bodies can be demonstrated by a method of selective staining developed by Nissl (Nissl staining), using an aniline stain to label extranuclear RNA granules. RNA stains blue with this method due to its basophilic (lat. "base-loving") properties.
These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis.
Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis).
de:Nissl-Färbunggl:Corpos de Nissl
|Histology: nervous tissue|
|Neurons (gray matter)||soma - axon (axon hillock, axoplasm, axolemma, neurofibril/neurofilament)
dendrite (Nissl body, dendritic spine, apical dendrite, basal dendrite)
types: bipolar - pseudounipolar - multipolar - pyramidal - Purkinje - granule
|Afferent nerve/Sensory nerve/Sensory neuron||GSA - GVA - SSA - SVA - fibers (Ia, Ib or Golgi, II or Aβ, III or Aδ or fast pain, IV or C or slow pain)|
|Efferent nerve/Motor nerve/Motor neuron||GSE - GVE - SVE - Upper motor neuron - Lower motor neuron (α motorneuron, γ motorneuron)|
|Synapses||neuropil - synaptic vesicle - neuromuscular junction - electrical synapse - Interneuron (Renshaw)|
|Sensory receptors||Meissner's corpuscle - Merkel nerve ending - Pacinian corpuscle - Ruffini ending - Muscle spindle
Free nerve ending
Olfactory receptor neuron - Photoreceptor cell - Hair cell - Taste bud
|Glial cells||Astrocyte (Radial glia) - Oligodendrocyte - Ependymal cells (Tanycytes) - Microglia|
|Myelination (white matter)||CNS: Oligodendrocyte|
PNS: Schwann cell - Neurolemma - Nodes of Ranvier/Internode - Schmidt-Lanterman incisures
|Related connective tissues||epineurium - perineurium - endoneurium - nerve fascicle - meninges|