Nafcillin sodium directions for use
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Directions for Use
The container closure may be penetrated only one time after reconstitution using a suitable sterile transfer device or dispensing set which allows measured dispensing of the contents. Use of a syringe and needle is not recommended as it may cause leakage. Use of this product is restricted to a suitable work area, such as a laminar flow hood. The withdrawal of container contents should be accomplished without delay. However, should this not be possible, a maximum of 4 HOURS from initial closure entry is permitted to complete fluid transfer operations. This time limit should begin with the introduction of solvent or diluent into the Pharmacy Bulk Package bottle.
For Administration by Intravenous Drip: Reconstitute as directed above (For Intravenous Use) prior to diluting with intravenous solution.
 |
Only those solutions listed above should be used for the intravenous infusion of nafcillin sodium. The concentration of the antibiotic should fall within the range specified. The drug concentration and the rate and volume of the infusion should be adjusted so that the total dose of nafcillin is administered before the drug loses its stability in the solution in use.
There is no clinical experience available on the use of this agent in neonates or infants for this route of administration.
This route of administration should be used for relatively short-term therapy (24 to 48 hours) because of the occasional occurrence of thrombophlebitis particularly in elderly patients.
If another agent is used in conjunction with nafcillin therapy, it should not be physically mixed with nafcillin but should be administered separately.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.[1]
References
Adapted from the FDA Package Insert.