Nafcillin

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Nafcillin
Systematic (IUPAC) name
7-[(2-ethoxynaphthalen-1-yl) carbonylamino]- 3,3-dimethyl-6-oxo-2-thia-5-azabicyclo [ 3.2.0] heptane-4-carboxylic acid
Identifiers
CAS number	985-16-0
ATC code	?
PubChem	8982
DrugBank	APRD01130
Chemical data
Formula	C21H22N2O5S
Mol. mass	414.476 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	<30% hepatic
Half life	?
Excretion	Biliary and renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	IM, IV

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Nafcillin sodium is a narrow spectrum beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, particularly species of Staphylococci, that are resistant to other penicillins.

Side effects

As with all penicillins, serious life-threatening allergic reactions can occur.

Milder side effects include:

• Nausea and vomiting
• Diarrhea, often due to suppression of normal gastrointestinal bacteria. Occasionally, this leads to a more serious super-infection with an organism like Clostridium difficile
• Abdominal pain
• Yeast infections (thrush) affecting the mouth and tongue or vagina