NUP214

Nucleoporin 214kDa
File:PBB Protein NUP214 image.jpg PDB rendering based on 2oit.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2oit​
Identifiers
Symbols	NUP214 ; CAIN; CAN; D9S46E; MGC104525; N214
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38008
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NUP214 202155 s at tn.png
File:PBB GE NUP214 211261 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nucleoporin 214kDa, also known as NUP214, is a human gene.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.

Further reading

• Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.CS1 maint: Multiple names: authors list (link)
• von Lindern M, Fornerod M, van Baal S; et al. (1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. PMID 1549122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• von Lindern M, Poustka A, Lerach H, Grosveld G (1990). "The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34". Mol. Cell. Biol. 10 (8): 4016–26. PMID 2370860.CS1 maint: Multiple names: authors list (link)
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. PMID 7584028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pilz A, Woodward K, Povey S, Abbott C (1995). "Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse". Genomics. 25 (1): 139–49. PMID 7774911.CS1 maint: Multiple names: authors list (link)
• Kraemer D, Wozniak RW, Blobel G, Radu A (1994). "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1519–23. PMID 8108440.CS1 maint: Multiple names: authors list (link)
• Stutz F, Izaurralde E, Mattaj IW, Rosbash M (1997). "A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus". Mol. Cell. Biol. 16 (12): 7144–50. PMID 8943370.CS1 maint: Multiple names: authors list (link)
• Fornerod M, van Deursen J, van Baal S; et al. (1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMID 9049309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. PMID 9114010.
• Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. PMID 9144189.CS1 maint: Multiple names: authors list (link)
• Bastos R, Ribas de Pouplana L, Enarson M; et al. (1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". J. Cell Biol. 137 (5): 989–1000. PMID 9166401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boer J, Bonten-Surtel J, Grosveld G (1998). "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis". Mol. Cell. Biol. 18 (3): 1236–47. PMID 9488438.CS1 maint: Multiple names: authors list (link)
• Bogerd HP, Echarri A, Ross TM, Cullen BR (1998). "Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1". J. Virol. 72 (11): 8627–35. PMID 9765402.CS1 maint: Multiple names: authors list (link)
• Zolotukhin AS, Felber BK (1999). "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev". J. Virol. 73 (1): 120–7. PMID 9847314.
• Schmitt C, von Kobbe C, Bachi A; et al. (1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO J. 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMID 10428971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bachi A, Braun IC, Rodrigues JP; et al. (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates". RNA. 6 (1): 136–58. PMID 10668806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herold A, Suyama M, Rodrigues JP; et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. 20 (23): 8996–9008. PMID 11073998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hofmann W, Reichart B, Ewald A; et al. (2001). "Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin". J. Cell Biol. 152 (5): 895–910. PMID 11238447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)