NMI (gene)
Jump to navigation
Jump to search
| N-myc (and STAT) interactor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NMI ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3441 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE NMI 203964 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
N-myc (and STAT) interactor, also known as NMI, is a human gene.[1]
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[1]
References
Further reading
- Bao J, Zervos AS (1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene. 12 (10): 2171–6. PMID 8668343.
- Lebrun SJ, Shpall RL, Naumovski L (1998). "Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi". J. Interferon Cytokine Res. 18 (9): 767–71. PMID 9781816.
- Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–30. PMID 9989503.
- Lee ND, Chen J, Shpall RL, Naumovski L (1999). "Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain". J. Interferon Cytokine Res. 19 (11): 1245–52. doi:10.1089/107999099312902. PMID 10574616.
- Bannasch D, Weis I, Schwab M (2000). "Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN". Oncogene. 18 (48): 6810–7. doi:10.1038/sj.onc.1203090. PMID 10597290.
- Zhou X, Liao J, Meyerdierks A; et al. (2000). "Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35". J. Biol. Chem. 275 (28): 21364–71. doi:10.1074/jbc.M003177200. PMID 10779520.
- Chen J, Shpall RL, Meyerdierks A; et al. (2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.
- Chen J, Naumovski L (2002). "Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells". J. Interferon Cytokine Res. 22 (2): 237–43. doi:10.1089/107999002753536211. PMID 11911807.
- Li H, Lee TH, Avraham H (2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.
- Sun GJ, Tong X, Dong Y; et al. (2002). "[Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (3): 369–72. PMID 12019454.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Jung HH, Lee J, Kim JH; et al. (2005). "STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell". FEBS Lett. 579 (18): 3941–6. doi:10.1016/j.febslet.2005.06.011. PMID 15996661.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Schlierf B, Lang S, Kosian T; et al. (2005). "The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi". J. Mol. Biol. 353 (5): 1033–42. doi:10.1016/j.jmb.2005.09.013. PMID 16214168.
- Zhang L, Tang Y, Tie Y; et al. (2007). "The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling". Cell. Signal. 19 (5): 932–44. doi:10.1016/j.cellsig.2006.11.002. PMID 17197158.
- Albihn A, Mo H, Yang Y, Henriksson M (2007). "Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling". Int. J. Cancer. 121 (8): 1821–9. doi:10.1002/ijc.22866. PMID 17565738.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |