Moricizine

Moricizine
Systematic (IUPAC) name
?
Identifiers
CAS number	31883-05-3
ATC code	?
PubChem	34633
DrugBank	APRD01124
Chemical data
Formula	C22H25N3O4S
Mol. mass	427.518 g/mol
Pharmacokinetic data
Bioavailability	38%
Protein binding	95%
Metabolism	?
Half life	3-4 hours (healthy volunteers), 6-13 hours (cardiac disease)
Excretion	?
Therapeutic considerations
Pregnancy cat.	B (U.S.)
Legal status
Routes	?

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Moricizine is a phenothiazine derivative with Vaughan Williams class IC antiarrhythmic properties. It undergoes extensive first-pass metabolism, has a bioavailability of 34-38 percent, and is 95 percent bound to plasma proteins. Moricizine is extensively metabolized and may have pharmacologically active metabolites. A recent clinical study has shown that moricizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations. Compared with disopyramide and quinidine, moricizine was equally or more effective in suppressing ventricular premature depolarizations, couplets, and nonsustained ventricular tachycardia. Further studies are needed comparing moricizine with other class 1 agents in the treatment of life-threatening arrhythmias; available data suggest that moricizine is comparable with these agents in the treatment of ventricular tachycardias and fibrillation. Moricizine appears to have a low incidence of serious adverse effects compared with other antiarrhythmics. This combination of apparently similar efficacy with a decreased incidence of adverse effects makes moricizine a worthwhile addition to currently available antiarrhythmic agents.

External links

• Moricizine
• MedlinePlus DrugInfo medmaster-a601080

de:Moricizin