Microscopic polyangiitis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [3]

Overview

The prevalence of Microscopic polyangiitis higher in Southern European countries and Asia.The incidence of GPA was similar to that of MPA.MPO‐ANCAs when positive in a patient was a marker of poor prognosis in the population of patients with AAV.

Epidemiology

Incidence

  • The incidence of Microscopic polyangiitis is approximately 3.3 per 100,000 individuals worldwide.[1]
  • Microscopic polyangiitis in Europe is seen with higher incidences in Southern countries than in Northern countries. [2]
  • The incidence of Microscopic polyangiitis is estimated to be 0.59 per 100,000 individuals per year in the United Kingdom.[3]
  • During the last two decades, the incidences of Microscopic polyangiitis has increased, which may be due to increased testing for various vasculitis as a result of availability of testing for ANCA.

Prevalence

  • The prevalence of Microscopic polyangiitis is approximately 42.1 per 100,000 individuals worldwide.[4]

Age

  • The incidence of Microscopic polyangiitis increases with age; the median age at diagnosis is 60 years.[5]

Gender

  • Males are more commonly affected with Microscopic polyangiitis than females (1.8:1).[5]

Race

  • Microscopic polyangiitis tends to affect individuals of Asian and Southern European descent.[6]

References

  1. Berti A, Cornec D, Crowson CS, Specks U, Matteson EL (December 2017). "The Epidemiology of Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis in Olmsted County, Minnesota: A Twenty-Year US Population-Based Study". Arthritis Rheumatol. 69 (12): 2338–2350. doi:10.1002/art.40313. PMID 28881446.
  2. Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
  3. Watts RA, Mooney J, Skinner J, Scott DG, Macgregor AJ (2012). "The contrasting epidemiology of granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis". Rheumatology (Oxford). 51 (5): 926–31. doi:10.1093/rheumatology/ker454. PMC 3465699. PMID 22258386.
  4. Berti A, Cornec D, Crowson CS, Specks U, Matteson EL (December 2017). "The Epidemiology of Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis in Olmsted County, Minnesota: A Twenty-Year US Population-Based Study". Arthritis Rheumatol. 69 (12): 2338–2350. doi:10.1002/art.40313. PMID 28881446.
  5. 5.0 5.1 Mohammad, A. J.; Jacobsson, L. T. H.; Mahr, A. D.; Sturfelt, G.; Segelmark, M. (2007). "Prevalence of Wegener's granulomatosis, microscopic polyangiitis, polyarteritis nodosa and Churg Strauss syndrome within a defined population in southern Sweden". Rheumatology. 46 (8): 1329–1337. doi:10.1093/rheumatology/kem107. ISSN 1462-0324.
  6. Fujimoto S, Watts RA, Kobayashi S, Suzuki K, Jayne DR, Scott DG, Hashimoto H, Nunoi H (October 2011). "Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the U.K". Rheumatology (Oxford). 50 (10): 1916–20. doi:10.1093/rheumatology/ker205. PMID 21798892.

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