Methaemoglobin

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

WikiDoc Resources for Methaemoglobin
Articles
Most recent articles on Methaemoglobin Most cited articles on Methaemoglobin Review articles on Methaemoglobin Articles on Methaemoglobin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Methaemoglobin Images of Methaemoglobin Photos of Methaemoglobin Podcasts & MP3s on Methaemoglobin Videos on Methaemoglobin
Evidence Based Medicine
Cochrane Collaboration on Methaemoglobin Bandolier on Methaemoglobin TRIP on Methaemoglobin
Clinical Trials
Ongoing Trials on Methaemoglobin at Clinical Trials.gov Trial results on Methaemoglobin Clinical Trials on Methaemoglobin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Methaemoglobin NICE Guidance on Methaemoglobin NHS PRODIGY Guidance FDA on Methaemoglobin CDC on Methaemoglobin
Books
Books on Methaemoglobin
News
Methaemoglobin in the news Be alerted to news on Methaemoglobin News trends on Methaemoglobin
Commentary
Blogs on Methaemoglobin
Definitions
Definitions of Methaemoglobin
Patient Resources / Community
Patient resources on Methaemoglobin Discussion groups on Methaemoglobin Patient Handouts on Methaemoglobin Directions to Hospitals Treating Methaemoglobin Risk calculators and risk factors for Methaemoglobin
Healthcare Provider Resources
Symptoms of Methaemoglobin Causes & Risk Factors for Methaemoglobin Diagnostic studies for Methaemoglobin Treatment of Methaemoglobin
Continuing Medical Education (CME)
CME Programs on Methaemoglobin
International
Methaemoglobin en Espanol Methaemoglobin en Francais
Businness
Methaemoglobin in the Marketplace Patents on Methaemoglobin
Experimental / Informatics
List of terms related to Methaemoglobin

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Methemoglobin (pronounced MET-hemoglobin) is a form of the oxygen-carrying protein hemoglobin (British English: haemoglobin), in which the iron in the heme group is in the Fe³⁺ state, not the Fe²⁺ of normal hemoglobin. Methemoglobin is unable to carry oxygen. It is chocolate-brown in color. The NADH-dependent enzyme methemoglobin reductase (AKA diaphorase I) is responsible for converting methemoglobin back to hemoglobin.

Normally one to two percent of people's hemoglobin is methemoglobin; a higher percentage than this can be genetic or caused by exposure to various chemicals and depending on the level can cause health problems known as Methemoglobinemia. A higher level of methemoglobin will tend to cause a pulse oximeter to read closer to 85% regardless of the true level of oxygen saturation.

Common causes

• Reduced cellular defense mechanisms
  • Children younger than 4 months exposed to various environmental agents
  • Methemoglobin reductase deficiency
  • G6PD deficiency
  • Hemoglobin M disease
  • Pyruvate kinase deficiency
• Various pharmaceutical compounds
  • Local anaesthetic agents, especially prilocaine as used in the Bier block
  • Amyl nitrite, chloroquine, dapsone, nitrates, nitrites, nitroglycerin, nitroprusside, phenacetin, phenazopyridine, primaquine, quinones and sulfonamides
• Environmental agents
  • Aromatic amines
  • Arsine
  • Chlorobenzene
  • Chromates
  • Nitrates/nitrites

Methemoglobinemia in infants

In children, this condition is known as blue baby syndrome, attributed primarily to excessive nitrate intake from drinking well water.

External links

• MeSH Methemoglobin

v • d • e WikiDoc Research Resources for Methaemoglobin
Articles on Methaemoglobin	Most recent articles on Methaemoglobin • Most cited articles on Methaemoglobin • Review articles on Methaemoglobin • Articles on Methaemoglobin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Methaemoglobin	Powerpoint slides on Methaemoglobin • Images of Methaemoglobin • Photos of Methaemoglobin • Podcasts & MP3s on Methaemoglobin • Videos on Methaemoglobin
Evidence Based Medicine Regarding Methaemoglobin	Cochrane Collaboration on Methaemoglobin • Bandolier on Methaemoglobin • TRIP on Methaemoglobin
Cost Effectiveness of Methaemoglobin	Cost Effectiveness of Methaemoglobin
Clinical Trials Involving Methaemoglobin	Ongoing Trials on Methaemoglobin at Clinical Trials.gov • Trial results on Methaemoglobin • Clinical Trials on Methaemoglobin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Methaemoglobin	US National Guidelines Clearinghouse on Methaemoglobin • NICE Guidance on Methaemoglobin • NHS PRODIGY Guidance • FDA on Methaemoglobin • CDC on Methaemoglobin
Textbook Information on Methaemoglobin	Books and Textbook Information on Methaemoglobin
Pharmacology Resources on Methaemoglobin	Dosing of Methaemoglobin • Drug interactions with Methaemoglobin • Side effects of Methaemoglobin • Allergic reactions to Methaemoglobin • Overdose information on Methaemoglobin • Carcinogenicity information on Methaemoglobin • Methaemoglobin in pregnancy • Pharmacokinetics of Methaemoglobin •
Genetics, Pharmacogenomics, and Proteinomics of Methaemoglobin	Genetics of Methaemoglobin • Pharmacogenomics of Methaemoglobin • Proteomics of Methaemoglobin
Newstories on Methaemoglobin	Methaemoglobin in the news • Be alerted to news on Methaemoglobin • News trends on Methaemoglobin
Commentary on Methaemoglobin	Blogs on Methaemoglobin
Patient Resources on Methaemoglobin	Patient resources on Methaemoglobin • Discussion groups on Methaemoglobin • Patient Handouts on Methaemoglobin • Directions to Hospitals Treating Methaemoglobin • Risk calculators and risk factors for Methaemoglobin
Healthcare Provider Resources on Methaemoglobin	Symptoms of Methaemoglobin • Causes & Risk Factors for Methaemoglobin • Diagnostic studies for Methaemoglobin • Treatment of Methaemoglobin
Continuing Medical Education (CME) Programs on Methaemoglobin	CME Programs on Methaemoglobin
International Resources on Methaemoglobin	Methaemoglobin en Espanol • Methaemoglobin en Francais
Business Resources on Methaemoglobin	Methaemoglobin in the Marketplace • Patents on Methaemoglobin
Informatics Resources on Methaemoglobin	List of terms related to Methaemoglobin

cs:Methemoglobin

da:Mæthæmoglobin de:Methämoglobin fr:Méthémoglobine it:Metaemoglobina

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .